Fourth quarter (October-
- Operating profit/loss amounted to
SEK -5,212,694 (-3,951,799). -
Loss for the period amounted to
SEK -4,749,222 (-3,898,340). -
Cash flow from operating activities totaled
SEK 3,503,148 (5,516,307). -
Earnings per share before dilution totaled
SEK -0.24 (-0.20). Earnings per share after dilution totaledSEK -0.24 (-0.20). -
Proposed dividend of
SEK 0.00 per share (0.00 for the preceding year).
Period (January-
- Operating profit/loss amounted to
SEK -17,096,277 (-19,362,750). -
Loss for the period amounted to
SEK -16,397,977 (-19,438,631). -
Cash flow from operating activities totaled
SEK -14,922,512 (-8,570,820). -
Earnings per share before dilution totaled
SEK -0.83 (-0,98). Earnings per share after dilution totaledSEK -0.83 (-0.98).
Key events during the fourth quarter
Nomination Committee for Elicera therapeutics appointed.-
Elicera changes Certified Adviser and Liquidity provider to
Carnegie Investment Bank AB (publ). -
Elicera submits GMP validation data to the
Swedish Medical Products Agency for the CARMA-study to supplement the conditionally approved clinical trial application. -
Elicera's co-founder receives a grant totalling 4.8 MSEK from the
Swedish Childhood Cancer Fund to support CAR T-cell research. - Elicera receive second part of EU grant amounting to 5.6 MSEK.
Key events during the period
- Elicera continues Phase I/IIa trial with oncolytic virus as planned, following safety review in cohort 3.
- Elicera submits Clinical Trial Application to evaluate its CAR T-cell therapy in B-cell lymphoma.
- Elicera appoints Anna Koptina Gültekin as Head of Regulatory Affairs.
-
Elicera hires
Erik Penser Bank as market maker - Elicera's annual meeting re-elect the board of directors
-
Elicera receives conditional approval from the
Medical Products Agency on its CAR T-cell Clinical Trial Application to test ELC-301 (CARMA-study) - Elicera receives Notice of Allowance for European patent protecting the iTANK[TM] platform
-
Elicera publishes a scientific article in
Nature Communications about the CAR T construct in the ELC-401 program
Key events after the end of the period
- Nomination committee appointed
-
Elicera participates in a collaborative project for the development of improved CAR T-cell production that has been awarded research support of
SEK 850 thousand . - Eliceras co-founder Magnus Essand invited to present the company's CAR T-cell projects at the world's largest cancer immunotherapy conference, CICON.
-
Elicera's Board of Directors proposes a rights issue of units of approximately
SEK 64 million . -
Elicera receives final approval from the
Medical Products Agency to initiate the CARMA-study with ELC-301. - No other key events that impact earnings or the financial position occurred after the end of the period
CEO Comments
Strategically important capitalization facilitates improvement of our development projects
Since
We were very happy to recently receive the MPA's final approval to start our planned CARMA-study with ELC-301 as we can now move forward and start treating patients. This marks a major and very significant milestone for the company. In pace with
our nearing the start of the clinical Phase I/IIa study, we see a clear need for strengthening the company's financial position. In mid-January, we therefore informed the market that we are conducting a preferential rights issue for a maximum of
We do not want to risk weakening our financial position and our need for
financing becoming acute since this would result in significantly poorer conditions for conducting a share issue on acceptable terms. By taking action in the present, we are staying a step ahead and we can start the CARMA-study as quickly as possible.
Apart from the financing of the CARMA-study, the proceeds from the share issue will also be used for the ongoing efforts to commercialize iTANK, the continued development of the company's other programs, and to strengthen the company's operational activities.
Approval to start CARMA-study
Final approval for initiating the CARMA-study was, as mentioned before, recently secured. The purpose of the study is to evaluate the safety and treatment efficacy of ELC-301, our most advanced CAR T-cell therapy, which focuses on the CD20 tumor target in patients with diffuse large B cell lymphoma, mantle cell lymphoma and indolent lymphoma who have suffered from relapses and lack other treatment alternatives.
The CARMA-study will be conducted in two stages: the first, with 12 patients, will evaluate the safety profile of the treatment and the optimal dosage level. We plan to report data from the first dosage group, consisting of three patients, already at the end of 2024 and complete results from all 12 patients in the second half of 2025.
The final report from the first part of the study will also include initial data on tumor response, which will be key to defining an optimal dosage in the second half of the study.
Strategic external partnerships strengthen the company's technology
In parallel with the development of our most advanced CAR T-cell drug candidate, ELC-301, work on the company's other CAR T-cell therapy continues. Early in the year, we announced that we had received
collaboration project with the Vecura R&D division at
Hospital and
Shortly thereafter, we were pleased to be notified that
co-founder and head of research, Professor Magnus Essand, had been awarded a total of
401 included - to induce immunity against brain tumors in children. Owing to Magnus's key efforts in the field, he has also been invited to speak at the prestigious
In the first half of 2024, we hope to be able to report on the findings of the AdVince Phase I/II study that is evaluating our drug candidate ELC-100. We have only one patient left to include in the dose-escalation study.
In conjunction with the report, we will provide a clearer description of the continued clinical development program.
High levels of activity in the global cell therapy industry
In 2023, we noted that a number of major transactions were being conducted in the field of cell therapy. In November, Novartis announced its purchase of a treatment for solid tumors, and just before Christmas it became known that
acquired a portfolio with both CAR T-cell therapies and the rights to CAR T-cell production technology. These are two of many key business events that highlight the maturity of the cell therapy industry and the increased rate of development of decisively important treatments for patients suffering from diseases that are difficult
to treat. In light of this, we see great potential in Elicera's drug candidates and our commercial platform technology, iTANK.
CEO and co-founder
The interim report has been approved by the board and the CEO for publication. The information was submitted for publication distributed through the contact person below at 08;12 CET on
For further information please contact:
Phone: +46 (0) 703 31 90 51
jamal.elmosleh@elicera.com
Certified Advisor
About the iTANK platform
The iTANK- (immunoTherapies Activated with NAP for efficient Killing) platform is the company's own fully developed commercially available technology platform for arming and enhancing CAR T-cells to meet two of the major challenges CAR T-cell therapies face in the treatment of solid tumors: tumor antigen heterogeneity and a hostile tumor microenvironment. The technology is used to incorporate a transgene into CAR T-cells encoding a neutrophil activating protein (NAP) from the bacterium Helicobacter pylori. Upon activation, NAP secreted from the CAR(NAP) T-cells has been shown to be able to enhance the function of the CAR T-cell in addition to activating a parallel immune response via CD8+ killer T-cells. This is expected to lead to a broad attack against most antigen targets on cancer cells. The iTANK-platform is used to enhance the company's own CAR T-cells but can also be universally applied to other CAR T-cell therapies under development. More information about iTANK-platform is available here: https://www.elicera.com/technology
About
For more information, please visit www.elicera.com
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