Celgene Corporation provided Unaudited earnings guidance for the fourth quarter and full year 2017 and full year of 2018. For the year 2017, GAAP diluted earnings per share is expected to be in the range of $3.64 to $4.19, a 57% year-over-year increase based on the mid-point of the range. GAAP operating margin is expected to be approximately 36%, an increase from 28% in the prior year, primarily due to increased product sales. Adjusted EPS is expected to be approximately $7.44, a 25% year-over-year increase. Adjusted operating margin is expected to be 58.1%, an increase of 310 basis points year-over-year. Total revenue is expected to be $13,003 million, a 16% year-over-year increase. For the fourth quarter 2017, GAAP LPS is expected to be in the range of $0.09 to EPS of $0.46, a 65% year-over-year decrease based on the mid-point of the range. GAAP operating margin is expected to be approximately 34%, an increase from 31% in the prior year, primarily due to increased product sales. Adjusted EPS is expected to be approximately $2.00, a 24% year-over-year increase. Adjusted operating margin is expected to be 55.3%, a decrease of 70 basis points year-over-year. Total revenue is expected to be $3,483 million, a 17% year-over-year increase. For the full-year 2018, total revenue is expected to be approximately $14.4 billion to $14.8 billion, a 12% increase year-over-year, based on the mid-point of the range. Based on GAAP, EPS is expected to be in the range of $6.58 to $6.95, excluding the impact of any strategic transactions, impairments, loss contingencies, changes in the fair value of equity investments and non-operating tax adjustments that have not yet occurred. Adjusted diluted EPS is expected to be in the range of $8.70 to $8.90, an 18% increase year-over-year, based on the mid-point of the range. Adjusted tax rate is expected to be approximately 18%, increase of 200 basis points year-over-year, change based on the mid-point of the range. GAAP operating margin is expected to be approximately $6.58 billion to $6.95 billion. Adjusted operating margin is expected to be approximately $8.70 billion to $8.90 billion, an 18% increase year-over-year, change based on the mid-point of the range. The company also reaffirmed 2020 long-term expected financial targets. 2020 total revenue range of $19.0 billion to $20.0 billion and adjusted diluted EPS to exceed $12.50.