CanSino Biologics Inc. announced that, the phase I trial for Recombinant Zoster Vaccine (Adenovirus Vector) (the Recombinant Zoster Vaccine) developed by the Group in co-operation with Vaccitech (UK) Limited, was officially initiated recently in Canada and the first trial patient case has been formally enrolled. Phase I trial for RecombinantZoster Vaccine (includes intramuscular injection and inhaled version) is to evaluate its safety and preliminary immunogenicity. The recombinant Zoster Vaccine adopts ChAdOx1 Vector technology route.

The Adenovirus Vector vaccine is capable of triggering cellular immunity and humoral immunity simultaneously, and the vaccine candidate also adopts internationally leading process technology and a quality management and control system that meets international standards. During the entire production process of the vaccine candidate, no animal derived ingredients are used to improve the safety of the final product. It is shown in the pre-clinical studies that the product was able to stimulate both humoral and cellular immunity simultaneously, with no significant difference in humoral immunity compared to Shingrix, a recombinant subunit adjuvanted vaccine developed by GlaxoSmithKline, and with systemic cellular immunity levels significantly higher than those of the Shingrix, which is expected to provide good protection.