PHILADELPHIA, VANCOUVER - BriaCell Therapeutics Corp. (NASDAQ: BCTX, BCTXW) (TSX: BCT) ('BriaCell' or the 'Company'), a clinical-stage biotechnology company that develops novel immunotherapies to transform cancer care, announces initiation of a first-in-human, Phase 1/2 study evaluating safety and efficacy of Bria-OTS, BriaCell's personalized off-the-shelf next generation immunotherapy, as monotherapy and in combination with PD-1 inhibitor tislelizumab , in advanced metastatic breast cancer.

'Advancing Bria-OTS as our second novel immunotherapy candidate into the clinic is a significant milestone for BriaCell. We believe personalization through our Bria-OTS immunotherapy platform will produce more potent and long-lasting responses than previously observed, with potential synergistic effects with the immune check point inhibitor,' stated Dr. William V. Williams, BriaCell's President & CEO. 'We are grateful to our scientific and clinical teams for the successful completion of the Institutional Review Board (IRB), Clinical Trial Site Agreement (CTA), and obtaining FDA authorization for the Investigational New Drug (IND) filings, as well as to our investors and collaborators for their support in bringing Bria-OTS one step closer to cancer patients.'

Giuseppe Del Priore, MD, MPH, BriaCell's Chief Medical Officer stated, 'The off-the-shelf nature of our treatment will allow the patients to be treated rapidly - which can be life changing for advanced metastatic breast cancer patients. Additionally, we expect the preferred safety profile of our personalized immunotherapy, Bria-OTS, to improve the quality of life and add months and even years to the lives of these heavily pretreated patients, a distinctive combination of benefits in late-stage cancer care.'

About Bria-OTS Platform

Awarded numerous US and international patents and supported by clinical data of Bria-IMT, BriaCell's lead clinical candidate - currently in a pivotal Phase 3 study for advanced metastatic breast cancer (ClinicalTrials.gov NCT06072612 ), Bria-OTS is BriaCell's personalized off-the-shelf immunotherapy platform, and the basis for BriaCell's 'OTS' strategy. Bria-OTS for advanced metastatic breast cancer is the first use of this platform. Similar cell lines are in development for prostate cancer (Bria-PROS+), lung cancer (Bria-LUNG+), and melanoma (Bria-MEL+).

An Investigational New Drug Application (IND) is currently open for the Bria-OTS breast cancer therapy also known as, Bria-BRES for advanced metastatic breast cancer. Bria-BRES will initiate a bucket trial (i.e. a study that investigates multiple product candidates in a single study) with other cancer indications.

Bria-OTS received a Small Business Innovation Research (SBIR) award from the National Cancer Institute (NCI).

About BriaCell Therapeutics Corp.

BriaCell is a clinical-stage biotechnology company that develops novel immunotherapies to transform cancer care.

Safe Harbor

This press release contains 'forward-looking statements' that are subject to substantial risks and uncertainties. All statements, other than statements of historical fact, contained in this press release are forward-looking statements. Forward-looking statements contained in this press release may be identified by the use of words such as 'anticipate,' 'believe,' 'contemplate,' 'could,' 'estimate,' 'expect,' 'intend,' 'seek,' 'may,' 'might,' 'plan,' 'potential,' 'predict,' 'project,' 'target,' 'aim,' 'should,' 'will,' 'would,' or the negative of these words or other similar expressions, although not all forward-looking statements contain these words. Forward-looking statements, including those about BriaCell's personalization through the Bria-OTS immunotherapy platform producing more potent and long-lasting responses than previously observed, with potential synergistic effects with the immune check point inhibitor; the preferred safety profile of Bria-OTS improving the quality of life and increasing the lifespan of heavily pretreated patients and Bria-BRES initiating a bucket trial with other cancer indications, are based on assumptions as to future events that may not prove to be accurate. These and other risks and uncertainties are described more fully under the heading 'Risks and Uncertainties' in the Company's most recent Management's Discussion and Analysis, under the heading 'Risk Factors' in the Company's most recent Annual Information Form, and under 'Risks and Uncertainties' in the Company's other filings with the Canadian securities regulatory authorities and the U.S. Securities and Exchange Commission, all of which are available under the Company's profiles on SEDAR+ at www.sedarplus.ca and on EDGAR at www.sec.gov . Forward-looking statements contained in this announcement are made as of this date, and BriaCell Therapeutics Corp. undertakes no duty to update such information except as required under applicable law.

Contact:

William V. Williams

Tel: 1-888-485-6340

Email: info@briacell.com

Jules Abraham

Email: julesa@coreir.com

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