Arrowhead Pharmaceuticals Inc. announced that it has submitted an Investigational New Drug Application (IND) to the U.S. Food and Drug Administration (FDA) for a Phase 2b dose-finding clinical study of ARO-ANG3, the company’s investigational RNA interference (RNAi) therapeutic being developed as a treatment for patients with mixed dyslipidemia. Following FDA’s review of the IND, the company intends to initiate AROANG3-2001, a Phase 2b dose-finding clinical study in patients with elevated triglycerides and low-density lipoprotein cholesterol (LDL-C). The primary objective of the study is to evaluate the safety and efficacy of ARO-ANG3 in adults with mixed dyslipidemia and to select a dosing regimen for later stage clinical studies in this patient population. The study is designed to include a total of 180 participants in three cohorts. All dose cohorts will enroll in parallel, with 60 participants per cohort randomly assigned in a 3:1 ratio to receive ARO-ANG3 or placebo.