Corporate Presentation
Christopher U Missling, PhD | President & CEO | Nasdaq: AVXL | November 2020 |
Forward Looking Statement
This presentation contains forward-looking statements made within the meaning of the Private Securities Litigation Reform Act of 1995 by Anavex® Life Sciences Corp. and its representatives. These statements can be identified by introductory words such as "expects," "plans," "intends," "believes," "will," "estimates," "forecasts," "projects," or words of similar meaning, and by the fact that they do not relate strictly to historical or current facts. Forward-looking statements frequently are used in discussing potential product applications, potential collaborations, product development activities, clinical studies, regulatory submissions and approvals, and similar operating matters. Many factors may cause actual results to differ from forward-looking statements, including inaccurate assumptions and a broad variety of risks and uncertainties, some of which are known and others of which are not. Known risks and uncertainties include those identified from time to time in reports filed by Anavex Life Sciences Corp. with the Securities and Exchange Commission, which should be considered together with any forward-looking statement. No forward-looking statement is a guarantee of future results or events, and one should avoid placing undue reliance on such statements. Anavex Life Sciences Corp. undertakes no obligation to update publicly any forward-looking statements, whether as a result of new information, future events or otherwise. Anavex Life Sciences Corp. cannot be sure when or if it will be permitted by regulatory agencies to undertake clinical trials or to commence any particular phase of any clinical trials. Because of this, statements regarding the expected timing of clinical trials cannot be regarded as actual predictions of when Anavex Life Sciences Corp. will obtain regulatory approval for any "phase" of clinical trials. We also cannot be sure of the clinical outcome for efficacy or safety of our compounds. Potential investors should refer to the risk factors in our reports filed on Edgar.
2
Broad Pipeline Targeting Neurodegenerative and
Neurodevelopmental Diseases with Significant Unmet Medical Need
CANDIDATE
ANAVEX®2-73 (Blarcamesine)
ANAVEX®3-71
(AF710B)
ANAVEX®1-41
ANAVEX®1066
* = Orphan Drug Designation by FDA
PRECLINICAL
ALZHEIMER'S DISEASE PARKINSON'S DISEASE DEMENTIA *RETT SYNDROME *RETT SYNDROME *RETT SYNDROME *INFANTILE SPASMS
FRAGILE X ANGELMAN'S
*FRONTOTEMPORAL DEMENTIA (FTD) ALZHEIMER'S DISEASE PARKINSON'S DISEASE
DEPRESSION
STROKE
PARKINSON'S DISEASE
ALZHEIMER'S DISEASE
VISCERAL PAIN
ACUTE & NEUROPATHIC PAIN
PHASE 1 | PHASE 2 | PHASE 3 |
AD ANAVEX®2-73-AD-004
ANAVEX®2-73-PDD-001
EXCELLENCE ANAVEX®2-73-RS-003
U.S. ANAVEX®2-73-RS-001 Fast Track, Rare Pediatric,
Orphan Drug (U.S./EU)
AVATAR ANAVEX®2-73-RS-002
ANAVEX®3-71-001
- Differentiated clinical-stage CNS assets targeting significant and growing markets
- Patent protection to 2030-2039, worldwide rights for all product candidates
3
Targeting Large Market Opportunities with Significant Unmet
Medical Need
All U.S. Patient Numbers
- Alzheimer's Disease Facts and Figures. Alzheimers Dement 2018;14(3):367-429.
2) | Marras C et al 2018. npj Parkinson's Disease volume 4, Article number: 21 | 4 |
3) | Based on prevalence number on orphanet |
Transformative Events for Anavex
- Rett Syndrome Program Received Fast Track Designation and is Eligible for Pediatric Priority Review Voucher
- Pursuing Large Markets with High Unmet Need by Applying Genetic Precision Medicine
- Novel CNS Mechanism of Action Upstream of Neurodevelopment and Neurodegeneration
- Compelling first Human Patient Data in Parkinson's Disease Dementia, Rett Syndrome and Alzheimer's Disease
- Sufficient Cash for >24 months To Achieve Key Milestones - Including non-dilutiveCash from Australian
Government for Alzheimer's Trial, and from Rettsyndrome.org for Rett Syndrome Trial
Continued Significant Value-creating Events with Several Clinical Readouts in 2020/2021:
- Two Phase 2 Adult Rett Syndrome Trials (ClinicalTrials.gov Identifier: NCT03758924, NCT03941444)
- Phase 2/3 Pediatric Rett Syndrome Trial (ClinicalTrials.gov Identifier: NCT04304482)
- Phase 2b/3 Alzheimer's Disease Trial (ClinicalTrials.gov Identifier: NCT03790709)
- Phase 1 of ANAVEX®3-71 with focus on Frontotemporal Dementia (ClinicalTrials.gov Identifier: NCT04442945)
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Catalysts to Drive Value
The company has multiple near-term clinical milestones
Full enrollment Phase 2 Parkinson's disease dementia (PDD)
Rett syndrome program received FDA Fast Track Designation and is eligible for FDA Pediatric Priority Review Voucher
Initiate EXCELLENCE Phase 2/3 in pediatric Rett syndrome (RTT) Initiate Phase 1 ANAVEX®3-71
Full enrollment U.S. Phase 2 RTT Topline data Phase 2 PDD
Topline data U.S. Phase 2 RTT - Q4 2020 Topline data AVATAR Phase 2 RTT - 1H 2021 Topline data Phase 1 ANAVEX®3-71 - 1H 2021
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Clinical Trials - MoA and First Clinical Data:
- Rett Syndrome (RTT)
- Alzheimer's Disease (AD)
- Parkinson's Disease Dementia (PDD)
ANAVEX®2-73 MoA: S1R Activation is Upstream from other Therapeutic Targets
Neural cells suffer functional loss in neurological disorders which causes cellular stress
Pathologies include:
ü Aβ, Tau and ApoE fragmentation and dysfunction
ü Proteinopathy
ü Microglia activation, migration, and dysregulation
ü Apoptosis feedback loops that lead to neuronal degradation
ü Autophagy dysfunction
ü Mitochondrial Dysfunction and Oxidative Stress that leads to further neuronal degradation
ü Neurodegeneration that spreads through a cascade of stress responses
S1R activates neuroprotective signals that help neurons return to homeostasis
S1R = Sigma-1 Receptor | 8 |
ANAVEX®2-73 Establishes Human Proof-of-Concept and SIGMAR1
Target Occupancy
2D [18F]FTC-146-PET imaging of ANAVEX®2-73: Dose-
dependent ANAVEX®2-73 Target Engagement
0 mg /kg | 1 mg/kg | 10 mg/kg | 30 mg/kg |
Receptor1-SigmaPercent | Occupancy | 100 | ||||||
80 | ||||||||
60 | ||||||||
40 | ||||||||
20 | ||||||||
0 | ||||||||
0 | 5 | 10 | 15 | 20 | 25 | 30 | ||
mg/kg of ANAVEX2-73 |
ANAVEX®2-73 positive response in functional
(ADCS-ADL*) outcome in Alzheimer's disease patients
correlate with SIGMAR1 mRNA levels
p=0.015 | p-value of Mann-Whitney U test | |||
SIGMAR1 RNA expression (TPM) | All n=20 patients in study. Slope of | |||
ADCS-ADL* from baseline to week 57 | ||||
with available genomic data | ||||
Decrease (Negative) | Increase (Positive) |
Source: Reyes S et al, AAIC 2018; Hampel H et al. Alzheimer's Dement. 2020;00:1-14; *Alzheimer's Disease Cooperative Study Activities of Daily Living 23-item scale (ADCS-ADL) | 9 |
SIGMAR1 Activation has been Shown to Modulate Multiple Aspects
of Neurodegenerative Processes
Sigma-1 receptor agonists have been shown to restore neuronal functions in neurodegenerative processes
ANAVEX®2-73 enhances autophagy and alleviates Tau pathology in neurodegenerative disease models
Sigma-1 receptor agonists have a neuroprotective effect in neurodegenerative disease models
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What is Rett Syndrome?
Devastating neuro-developmental disease in girls with both movement impairment and cognitive
impairment
Rett Syndrome (RTT)
- Non-inheritedgenetic postnatal disorder caused by mutations in the MECP2 gene
- Occurs almost exclusively in girls
- Leads to severe impairments, affecting nearly every aspect of the child's life
- Impairment includes ability to speak, walk, eat and even breathe easily
- Hallmark of RTT is near constant repetitive hand movements while awake
- Occurs worldwide in approximately one in every 10,000 to 15,000 live female births
Source: https://www.rettsyndrome.org/about-rett-syndrome | 11 |
Phase 2 PART A: Improvement in All Key Domains
U.S. Rett Syndrome ANAVEX®2-73-RS-001 Trial (NCT03758924)
SUMMARY
- Phase 2, safety, tolerability, efficacy for 7 weeks, oral, liquid formulation, 5 mg daily (relatively low dose)
- Part A: Intensive PK, n=6, Completed
- Part B: Randomized, double-blind,placebo-controlled, n=25, ongoing
- Females > 18 years, classic RTT w/MECP2 mutation
- Evaluations at baseline (Week 0), Week 4 & Week 7 (End of Treatment)
- Good safety and tolerability: No serious adverse events, only three grade 1-2 adverse events
EFFICACY*
-
Global severity RSBQ and CGI-I
RSBQ = Rett Syndrome Behavior Questionnaire CGI-I = Clinical Global Impressions - Improvements - Secondary: Behavior (ADAMS), Sleep (CSHQ), VAS (top caregiver concerns), Seizure diary
- Response Biomarker*: Glutamate, GABA; Genetic biomarker: DNA & RNA profiles
RSBQ Total | RSBQ Hand Behaviors | |||||||||||||
0 | Baseline | Week 7 | 0 | Baseline | Week 7 | |||||||||
10 | Behaviors | 1 | ||||||||||||
2 | ||||||||||||||
Total | 20 | |||||||||||||
3 | ||||||||||||||
p = 0.027 | ||||||||||||||
30 | 4 | |||||||||||||
RSBQ | RSBQHand | 5 | ||||||||||||
40 | RSBQ | |||||||||||||
8 | ||||||||||||||
6 | ||||||||||||||
50 | 7 | |||||||||||||
60 | p = 0.042 | |||||||||||||
improves by | 9 | |||||||||||||
70 | over 30% | 10 | ||||||||||||
*Preliminary evaluation of efficacy: two-tailed, nonparametric tests (conservative)
RSBQ Breathing Problems
Baseline | Week 7 |
0 |
Problems | 2 | |||||||
Breathing | 4 | |||||||
8 | ||||||||
RSBQ | 6 | |||||||
10 | p = 0.042 | |||||||
12 | ||||||||
Sleep - CSHQ-Waking During the Night
0 | Baseline | Week 7 | ||||||||
During | 0.5 | |||||||||
1 | ||||||||||
Waking-CSHQ | Nightthe | 1.5 | ||||||||
2 | ||||||||||
2.5 | ||||||||||
3 | ||||||||||
- | 3.5 | |||||||||
p = 0.042 | ||||||||||
4.5 | ||||||||||
Sleep | ||||||||||
4 | ||||||||||
5 | ||||||||||
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Precision Medicine
Biomarkers Increase Probability of
Success
76%
55%
46%
28%
Phase II to Phase III | Phase III to NDA/BLA | ||
Without Biomarkers | With Patient Selection Biomarkers | ||
Thomas DW et al. Clinical Development Success Rates 2006-2015. BIO Industry Analysis
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In patients with RTT, MeCP2 deficiency leads to increased levels of Glutamate, in comparison to healthy controls1,2,3, which results in excitatory-inhibitory imbalance and further synaptic dysfunction
Loss of synaptic homeostasis can impair nerve cells (neurons) and their connections
Glutamate as potential biomarker of microglia activation and
synaptic dysfunction
- Hamberger, A., et al., Elevated CSF glutamate in Rett syndrome. Neuropediatrics, 1992. 23(4): p. 212-3.;2) Lappalainen, R. and R.S. Riikonen, High levels of cerebrospinal fluid glutamate in Rett syndrome. Pediatr Neurol, 1996. 15(3): p. 213-6; 3) J.L. Neul at al., Metabolic signatures differentiate Rett syndrome from unaffected siblings.
Frontiers in Integrative Neuroscience (2020) Vol14, Art 7, doi:10.3389/fnint.2020.00007 | 14 |
Phase 2 PART A: Reported Improvements Correlate with Biomarkers
U.S. Rett Syndrome ANAVEX®2-73-RS-001 Trial (NCT03758924)
REPORT on PART A: INTENSIVE PK SUBCOHORT
- Plasma levels of the biomarker Glutamate decreased significantly (Week 0 vs. Week 7; 2-tailed Wilcoxon signed rank test, p = 0.046)
- Levels of Glutamate at Week 7 directly correlated with CGI-I scores at Week 7 (2-tailed Spearman's rho = 0.837, p = 0.038)
- Greater decreases in Glutamate associated with greater improvement in these efficacy scores
- GABA changes demonstrated an inverse correlation of the magnitude of Glutamate changes (2- tailed Spearman's rho = -0.829, p = 0.042)
Glutamate (∝mo/L)
0
10
20
30
40
50
60
70
Glutamate
Baseline | Week 7 |
p = 0.046
Glutamate
decreases by
over 40%
Significant Correlations: RSBQ & CGI-I
7 | 5 | ||
Iat Week | 4 | ||
3 | |||
CGI- | |||
2 | |||
p = 0.003 | |||
1 | |||
0 | 20 | 40 |
RSBQ Total at Week 7
Improvement
Glutamate & CGI-I
5 | ||||
Week 7 | 4 | |||
3 | ||||
CGI-I | 2 | |||
60 | p = 0.038 | |||
1 | ||||
10.00 | 20.00 | 30.00 | 40.00 |
Glutamate ∝mol/L Week 7
RSBQ Hand Behaviors Week 7
Glutamate & Hand Behaviors | Glutamate & Sleep | |||||||
8 | 40 | |||||||
7 | 7 | |||||||
Visit | 35 | |||||||
6 | ||||||||
5 | Total | 30 | ||||||
4 | CSHQ- | 25 | ||||||
3 | ||||||||
20 | ||||||||
2 | p = 0.021 | Sleep | p = 0.005 | |||||
1 | ||||||||
15 | ||||||||
0 | ||||||||
-100 | -50 | 0 | 50 | 10 | ||||
% Change in Glutamate | 10.00 | 20.00 | 30.00 | 40.00 |
Glutamate ∝mol/L Week 7
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ANAVEX®2-73 Phase 2 U.S. Rett Syndrome Study
N=31*
RTT patient population | ANAVEX®2-73 |
Active dose# |
- Diagnosis of confirmed RTT
• | Patients age >18 | Randomization |
• | Entire DNA and RNA | 3:2 |
sequencing |
ANAVEX®2-73-RS-001 STUDY ()*
Placebo
- Includes a 6 patient cohort undergoing a 7-week pharmacokinetic (PK) assessment with safety, tolerability, pharmacokinetic and efficacy evaluation of ANAVEX®2-73
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Primary and Secondary Endpoints
- PK, safety and tolerability of ANAVEX®2-73
- Behavioral symptoms
- Sleep function
- Seizure activity
Pre-specified Endpoints
- Genetic variants SIGMAR1 (rs1800866), COMT (rs113895332/rs61143203) with influence on treatment effect
# Oral liquid solution once daily; Dose restricted to maintain complete blinding | 16 |
ANAVEX®2-73 Phase 2 Rett Syndrome AVATAR Study
N=33*
RTT patient population | ANAVEX®2-73 |
Active dose# |
- Diagnosis of confirmed RTT
• | Patients age >18 | Randomization |
• | Entire DNA and RNA | 3:2 |
sequencing |
ANAVEX®2-73-RS-001 STUDY (NCT0
Placebo
- Includes a 3 patient cohort undergoing a 3-week pharmacokinetic (PK) assessment with safety, tolerability, pharmacokinetic and efficacy evaluation of ANAVEX®2-73
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Primary and Secondary Endpoints
- Safety and tolerability of ANAVEX®2-73
- Behavioral symptoms
- Sleep function
- Seizure activity
Pre-specified Endpoints
- Genetic variants SIGMAR1 (rs1800866), COMT (rs113895332/rs61143203) with influence on treatment effect
# Oral liquid solution once daily; Dose restricted to maintain complete blinding | 17 |
ANAVEX®2-73-RS-003 Rett Syndrome EXCELLENCE Study
N>69
RTT patient population | ANAVEX®2-73 |
Active dose# |
- Diagnosis of confirmed RTT
• | Patients age 5-18 | Randomization |
• | Entire DNA and RNA | 2:1 |
sequencing |
ANAVEX®2-73-RS-001 STUDY (NCT037
Placebo
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Primary and Secondary Endpoints
- Safety and tolerability of ANAVEX®2-73
- Behavioral symptoms
- Sleep function
- Seizure activity
Pre-specified Endpoints
- Genetic variants SIGMAR1 (rs1800866), COMT (rs113895332/rs61143203) with influence on treatment effect
# Oral liquid solution once daily; Dose restricted to maintain complete blinding | 18 |
Alzheimer's Disease (AD)
Alzheimer's disease is a progressive, irreversible neurological disease and the most common cause of
dementia
Alzheimer's Disease (AD)
- Alzheimer's disease incidence highly correlates with age
- AD prevalence in US:~5,700,000
- Estimated 50 million people live with dementia worldwide
- Today, there are no commercially available therapies to address the underlying cause of Alzheimer's
- The current annual cost of dementia is estimated at $1 trillion, a figure set to double by 2030
Source: www.alz.org/alzheimers-dementia/what-is-dementia/types-of-dementia/parkinson-s-disease-dementia | 19 |
ANAVEX®2-73 Demonstrated Improved MMSE1 and ADCS-ADL2 Scores in Phase 2a AD
Study through 148 Weeks
Adjusted change in MMSE1 (±SE)
N=8
N=13
p-value < 0.0008
Adjusted change in ADCS-ADL2 (±SE)
N=8
N=13
p-value < 0.0001
Source: Hampel et al. A precision medicine framework using artificial intelligence for the identification and confirmation of genomic biomarkers of response to an Alzheimer's disease therapy: Analysis of the blarcamesine (ANAVEX2-73) Phase 2a clinical study. Alzheimer's Dement. 2020;00:1-14
- Mini Mental State Examination (MMSE)
2 Alzheimer's Disease Cooperative Study Group - Activities of Daily Living Inventory (ADCS-ADL) | 20 |
ANAVEX®2-73 Phase 2b/3 Alzheimer's Disease and ATTENTION-AD OLE Study
N=450
Early AD patient population
- Confirmed amyloid pathophysiology (CSF/amyloid PET)
- Patients aged 60 to 85 years
- MMSE score 20-28
- Entire DNA and RNA sequencing
ANAVEX®2-73
High dose#
Randomization | ANAVEX®2-73 |
1:1:1 | Medium dose# |
Placebo
48
… and Open Label Extension (OLE) 96weeks
Primary Endpoints
- ADAS-Cog
- ADCS-ADL
- Safety and tolerability of ANAVEX®2-73
Key Secondary Endpoints
- CDR-SB
- Structural and functional MRI
- Biomarkers: Abeta40/Abeta42, T-tau,P-tau, NFL, YKL-40, neurogranin, BACE1
Pre-specified Endpoints
- Genetic variants SIGMAR1 (rs1800866), COMT (rs113895332/rs61143203) with influence on treatment effect
# Oral capsule once daily; Dose restricted to maintain complete blinding | 21 |
Parkinson's Disease Dementia (PDD)
Up to 80 percent of those with Parkinson's disease eventually experience Parkinson's disease dementia
Parkinson's Disease Dementia
- Parkinson's disease is a fairly common neurological disorder in older adults, estimated to affect nearly 2 percent of those older than age 65
- PD prevalence in US:~1,000,000
- The brain changes caused by Parkinson's disease begin in a region that plays a key role in movement
- Highly heterogeneous multisystem disorder
- Etiology of cognitive impairment in PD has not yet been fully elucidated
- As Parkinson's brain changes gradually spread, they often begin to affect mental functions, including memory and the ability to pay attention, make sound judgments and plan the steps needed to complete a task
Source: Aarsland D, Creese B, Politis M, Chaudhuri KR, Ffytche DH, Weintraub D, Ballard C. Cognitive decline in Parkinson disease. Nat Rev | |
Neurol. 2017 Apr;13(4):217-231. doi: 10.1038/nrneurol.2017.27. Epub 2017 Mar 3. PMID: 28257128; PMCID: PMC5643027; | |
www.alz.org/alzheimers-dementia/what-is-dementia/types-of-dementia/parkinson-s-disease-dementia | 22 |
ANAVEX®2-73 PoC Phase 2 PDD Study Design
A Phase 2 trial to Assess the Safety, Tolerability and Efficacy of ANAVEX®2-73 (blarcamesine) Oral Capsules in the Treatment of Parkinson's Disease Dementia
1:1:1 randomization
2-week baseline period | 3-weekup-titration period | 11-week target dose treatment period | Study data collected | |||||||
at Baseline, Week 8 | ||||||||||
Screening | Baseline | Week 3 | Week 8 | Week 14 | and 14 | |||||
N=44 | ANAVEX®2-73 High Dose | |||||||||
(10, 20, 30, then 50 mg QD) | ||||||||||
2-week baseline | ||||||||||
ANAVEX®2-73 Medium Dose | ||||||||||
N=132 | including | N=44 | ||||||||
actigraphy | (10, 20, then 30 mg QD) | |||||||||
N=44 | Placebo | |||||||||
(QD) | QD = once per day | |||||||||
- PDD Patient Population
- Diagnosis of probable Parkinson's disease dementia
- Diagnosis of idiopathic Parkinson's disease
- Patients aged ≥ 50 years
- MoCA score 13-23
- Key Primary and Secondary Endpoints
- Safety and tolerability
- CDR Cognitive Domain of Attention
- Sleep function
- MDS-UPDRS
- Actigraphy (24-hour monitoring)
- Entire DNA and RNA sequencing
- Pre-specifiedEndpoints
- Genetic variants SIGMAR1 (rs1800866),
- COMT(rs113895332/rs6114320 3) with influence on treatment effect
ANAVEX®2-73-PDD- 001 is a Proof of Concept (PoC) Phase 2, multicenter, randomized, double- blind, placebo- controlled, parallel- group, 3-arm, 14- week study
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Key Cognitive Domains
Key cognitive features addressed by ANAVEX®2-73 (blarcamesine)
The criteria from the National Institute on Aging and Alzheimer's Association (NIA-AA) workgroup mention the following five cognitive domains when diagnosing MCI-AD:
- Episodic memory
- Attention
- Language
- Visuospatial skills
- Executive functions
Related CDR
system
domains
Episodic memory
Choice reaction time
Word recognition
Picture recognition
Numeric working memory
Source: Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH.
The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups
on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011 May;7(3):270-9. doi: 10.1016/j.jalz.2011.03.008. Epub 2011 Apr 21. PMID: 21514249; | 24 |
PMCID: PMC3312027. |
Significant Improvements in Episodic Memory with Increased Dose
ANAVEX®2-73-PDD-001 Study: Dose-dependent, statistically significant
improvement of Quality of Episodic Memory with ANAVEX®2-73 (blarcamesine)
Direction of
Improvement
(counts)
Quality of Episodic Memory (counts)
All participants
Time: 14 weeks change from baseline
• A high score reflects
ability to store, hold | ||
and retrieve | ||
information of an | ||
episodic nature (e.g., | ||
21.40 | an event or name) | |
-1.20 | +42.22 | • CDR system Quality |
of Episodic Memory | ||
-20.82 | highly correlated |
(70%) with ADAS-Cog | |
(r = 0.7)1 |
1. Wesnes K, Edgar C, Andreasen N, Annas P, Basun H, Lannfelt L, et al. Computerized cognition assessment during acetylcholinesterase inhibitor treatment in Alzheimer's disease. Acta Neurol Scand 2010; 122:270-7
All participants; ANAVEX2-73 = Active 30 mg, Active 50 mg vs Placebo | 25 |
J-T test based on actual maintenance dose: p = 0.003 |
Summary of Topline Results:
Broad and Significant Effects with ANAVEX®2-73 (blarcamesine) in PDD Patients
- ANAVEX®2-73 (blarcamesine): a novel, oral, investigational sigma-1 receptor (Sig-1R / SIGMAR1) agonist with multimodal activity
- Data confirm SIGMAR1 as gene "signature" biomarker of response to ANAVEX®2-73 (blarcamesine) confirming SIGMAR1 activation as mechanism of action
- Broad and statistically significant improvements in CDR system Cognitive Domain of Attention assessed by Choice Reaction Time (p = 0.039) and Digital Vigilance (p = 0.008) and CDR system Episodic Memory (p = 0.047), representing complex cognitive tasks with impact on quality of life such as making a choice between similar objects and remembering daily personal experiences, which are mostly impaired in both PD and AD1
- Statistically significant dose-dependent (p = 0.003) improvement of CDR system Episodic Memory, which has been shown to be highly correlated (70%) with the Alzheimer's Disease Assessment Scale-Cognitive score (ADAS-Cog; r = 0.7)2
- ANAVEX®2-73 (blarcamesine) does not impair sleep and has a positive effect on REM sleep behavior disorder
- ANAVEX®2-73 (blarcamesine) was generally safe, well tolerated, and improved safety profile compared to dementia drugs associated with typical adverse effects
- These results support continued development in PDD / PD as well as currently ongoing Phase 2 and Phase 2/3 clinical studies with ANAVEX®2-73 (blarcamesine) in Rett syndrome3 and Alzheimer's disease4
- Data will be submitted to the U.S. Food and Drug Administration to seek regulatory guidance
- Mahurin, R. K., & Pirozzolo, F. J. (1993). Application of Hick's law of response speed in Alzheimer and Parkinson diseases. Perceptual and Motor Skills, 77(1), 107-113
- Wesnes K, Edgar C, Andreasen N, Annas P, Basun H, Lannfelt L, et al. Computerized cognition assessment during acetylcholinesterase inhibitor treatment in Alzheimer's disease. Acta Neurol Scand 2010; 122:270-7
- ClinicalTrials.gov Identifiers: NCT03758924, NCT03941444, NCT04304482
- ClinicalTrials.gov Identifiers: NCT03790709, NCT02756858
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Anavex is pursuing Large Markets by Applying Precision Medicine to Develop Treatments for both Global Aging CNS diseases (Alzheimer's, Parkinson's), as well as catastrophic Orphan Genetically caused diseases, Rett Syndrome with High Unmet Needs
$ 277B
Economic burden
2018 Alzheimer'sAssociation
OVERARCHINGMESSAGE
A novel approach is needed to address the totality of CNS diseases
PRECISION MEDICINE IMPROVES CHANCE OF CLINICAL SUCCESS
Testing for biomarkers demonstrated improved clinical response to ANAVEX®2-73 in Rett syndrome correlated with glutamate and for Alzheimer's and Parkinson's patients carrying wild-type (WT) SIGMAR1 gene
NOVEL CNS MECHANISM OF ACTION
ANAVEX®2-73, an orally available Sigma-1 receptor agonist, is upstream of neurodevelopment and neurodegeneration and has been shown to restore homeostasis
COMPELLING INITIAL HUMAN DATA
ANAVEX®2-73 Phase 2 Parkinson's disease dementia, ongoing Phase 2 in Rett syndrome and Phase 2a trial in Alzheimer's with favorable safety and initial efficacy results through 148 weeks
WORLDWIDE COMMERCIAL RIGHTS AND STRONG IP FOUNDATION
We retain global commercial rights to all of our product candidates and our lead product candidate, ANAVEX®2-73, including patent protection to 2030-2039
SUFFICIENT CASH TO ACHIEVE KEY MILESTONES Sufficient cash for >24 months to achieve key milestones, including non-dilutive cash from Australian government for Alzheimer 's trial and from Rettsyndrome.org for Rett syndrome trial
27
Anavex Life Sciences Expertise
Management Team
Christopher U. Missling PhD - President & CEO
Walter E Kaufmann, MD - Chief Medical Officer
Stephan Toutain, MS, MBA - Chief Operating Officer
Emmanuel O Fadiran, RPh, PhD - SVP of Regulatory Affairs
Daniel Klamer, PhD - VP of Business Development & Scientific Strategy
Scientific Advisory Board Members
Jeffrey Cummings, MD | Paul Aisen, MD | |||||
Corinne Lasmezas, PhD | Norman Relkin, MD, PhD | |||||
Ottavio Arancio, MD, PhD | Jacqueline French, MD | |||||
Andrew Cole, MD | Dag Aarsland, MD, PhD | |||||
Daniel Weintraub, MD | Tangui Maurice, PhD | 28 | ||||
Contact Us
Corporate Office
Anavex®Life Sciences Corp. 51 West 52nd Street, 7th floor
New York, NY 10019 1-844-689-3939
Shareholder & Media Relations
ir@anavex.com
www.anavex.com
NASDAQ: AVXL
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Anavex Life Sciences Corp. published this content on 10 November 2020 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 20 November 2020 21:06:00 UTC