Item 5.07. Submission of Matters to a Vote of Security Holders

The 2022 Annual Meeting of Stockholders (the "Annual Meeting") of Alnylam Pharmaceuticals, Inc. (the "Company") was held on May 18, 2022. As of March 28, 2022, the record date for the Annual Meeting, 120,718,462 shares of the Company's common stock were issued and outstanding. A summary of the matters voted upon by stockholders at the Annual Meeting is set forth below.



1. The Company's stockholders re-elected the three persons listed below as
Class III directors, each to serve until the Company's 2025 annual meeting of
stockholders or until her successor is duly elected and qualified. The voting
results were as follows:

                                                 Votes                            Broker
                              Votes For         Against        Abstentions       Non-Votes
Margaret A. Hamburg, M.D.     103,694,086       2,137,148            28,581       4,486,234
Colleen F. Reitan             105,011,439         835,726            12,650       4,486,234
Amy W. Schulman               101,990,270       3,856,744            12,801       4,486,234


The terms of office of the following directors continued after the Annual
Meeting:

Dennis A. Ausiello, M.D.
Michael W. Bonney
Olivier Brandicourt, M.D.
Marsha H. Fanucci
Yvonne L. Greenstreet, MBChB, MBA
David E.I. Pyott
Phillip A. Sharp, Ph.D.

2. The Company's stockholders approved the proposed Amendment and Restatement of the Company's 2018 Stock Incentive Plan, as amended. The voting results were as follows:



Votes For    Votes Against   Abstentions   Broker Non-Votes
93,418,119    12,424,671       17,025         4,486,234

3. The Company's stockholders approved, in a non-binding advisory vote, the compensation of the Company's named executive officers. The voting results were as follows:



Votes For    Votes Against   Abstentions   Broker Non-Votes
95,318,086    10,517,203       24,526         4,486,234

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4. The Company's stockholders ratified the appointment by the Company's Board of Directors of PricewaterhouseCoopers LLP as the Company's independent auditors for the fiscal year ending December 31, 2022. The voting results were as follows:



 Votes For    Votes Against   Abstentions   Broker Non-Votes
109,725,390      611,520         9,139             0

Item 9.01. Financial Statements and Exhibits



  (d) Exhibits



        104 Cover Page Interactive Data File (embedded within the Inline XBRL
            document).

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