Aequus Pharmaceuticals Inc. announced that it has agreed to an extension of terms for its promotional service agreement with Sandoz on Tacrolimus immediate-release (“Tacrolimus IR”) to December 31st, 2022. Aequus began Canadian promotional efforts in 2016 for Sandoz's generic Tacrolimus. Through targeted awareness, valued added services, and customized support for both provincial and transplant centre stakeholders, Aequus has achieved a 4-Year CAGR of almost 20% for the Sandoz Tacrolimus brand.

The following information is based on the Product Monograph for tacrolimus IR. Please refer to the full Product Monograph for all labeled safety information for tacrolimus IR. TRANSPLANTATION: Prophylaxis of organ rejection in patients receiving allogeneic liver, kidney, or heart transplants.

Treatment of refractory rejection in patients receiving allogeneic liver or kidney transplants. Tacrolimus is to be used concomitantly with adrenal corticosteroids and other immunosuppressive agents. The safety and efficacy of the use of tacrolimus with sirolimus has not been established.

Only physicians experienced in immunosuppressive therapy and management of organ transplant should prescribe tacrolimus. Patients receiving the drug should be managed in facilities equipped and staffed with adequate laboratory and supportive medical resources. The physician responsible for maintenance therapy should have complete information requisite for the follow-up of the patient.

RHEUMATOID ARTHRITIS: Treatment of active rheumatoid arthritis in adult patients for whom disease modifying anti-rheumatic drug (DMARD) therapy is ineffective or inappropriate. Tacrolimus may be used as monotherapy or in combination with non-steroidal anti-inflammatory drugs (NSAIDs) and/or steroids, although the possibility of increased toxicity has not been fully explored.