Aclaris Therapeutics, Inc. announced the completion of enrollment into ATI-1777-AD-202, its Phase 2b trial of its investigational topical ?soft? Janus kinase (JAK) 1/3 inhibitor, ATI-1777, in patients with mild to severe atopic dermatitis. Aclaris anticipates releasing top-line efficacy, safety and other preliminary data from this trial around the end of this year.

ATI-1777 is a topical JAK inhibitor designed to minimize systemic exposure and delivered in a spray-on solution. The Phase 2b trial follows the successful four-week Phase 2a trial in moderate to severe atopic dermatitis which demonstrated meaningful improvement in the modified Eczema Area and Severity Index (EASI) and minimal measurable systemic exposure with a 2% formulation applied twice daily. The Phase 2b vehicle-controlled trial in atopic dermatitis further explores the concentration range (0.5%, 1% and 2%), as well as a once-daily regimen using the 2% formulation.

The trial enrolled 250 patients with mild, moderate or severe AD, including adults and children as young as 12-years-old, across 34 clinical trial sites in the U.S. The primary efficacy endpoint is the percent change in EASI over a period of 4 weeks. Secondary measures of efficacy, as well as safety and pharmacokinetics, will also be assessed.