Abpro Corporation announced the results of a Phase 1 study demonstrating a favorable safety and pharmacokinetic profile of ABP 300, a human neutralizing antibody for the treatment of COVID-19 derived from patients who have recovered from the SARS-CoV-2 infection. The Phase 1 clinical trial was conducted in 42 healthy subjects and showed safety and pharmacokinetic data at doses from 4 mg/kg to 60 mg/kg. Following the completion of this Phase 1 in December 2020, a series of Phase 2/3 registrational studies of ABP 300 has recently been initiated. ABP 300 is a novel human antibody therapy that neutralizes COVID-19 by binding to the Receptor Binding Domain (RBD) of the SARS-CoV-2 spike protein, blocking the viral interaction with the angiotensin-converting enzyme 2 (ACE2) receptors of host which are critical for viral entry and infection. Through this mechanism of action, ABP 300 not only completely neutralizes COVID-19 in animal models but could potentially do so more safely and more effectively than other monoclonal antibodies already approved and in clinical development. A study validating the efficacy of ABP 300’s mechanism of action in non-human primate models was recently published in Nature Communications. ABP 300 was developed to confer design features that potentially allow for more potent viral neutralization, higher efficacy against a larger number of strains, and enhanced safety benefits due to reduced antibody dependent enhancement (ADE), a potential adverse side effect of monoclonal antibody therapies.