Effective May 27, 2021, the Board of Directors of 180 Life Sciences Corp., with the recommendation of the Nominating and Corporate Governance Committee of the Board of Directors, appointed Russell T. Ray, MBA and Teresa DeLuca MD, MBA as members of the Board of Directors (“Board”), to fill the two vacancies on the Board (the “Appointees” and the “Appointments”), which Appointments will be effective on June 15, 2021 (the “Effective Date”). Mr. Ray and Dr. DeLuca were appointed as Class I and Class II directors, respectively, and will serve until the Company’s 2021 Annual Meeting of Stockholders (Mr. Ray) and the 2022 Annual Meeting of Stockholders (Dr. Deluca), until their successors have been duly elected and qualified, or until their earlier death, resignation or removal. The Board of Directors has not yet determined which committees of the Board of Directors Mr. Ray or Dr. DeLuca will be appointed to.