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NESS-ZIONA,
Vaxil is increasing its attention and resource allocation to establish an effective oral delivery mechanism across its Signal Peptide ("SP") platform as a way to distinguish the platform for treatment in oncology and infectious diseases. Last year, the Company announced positive signs of an immune response which were observed in an exploratory oral delivery experiment. In pursuit of this strategy, Vaxil has commenced pre-clinical work to further establish the ability to generate an immune response with an oral delivery mechanism. This work is being done both independently as well as in partnership with an established oral delivery company. Further updates will be provided when available.
In addition, Vaxil has put its COVID-19 vaccine work on temporary hold, as a result of how the COVID-19 vaccine market has evolved and the success of early entrants. The Company has determined it will better serve patients and shareholders to use its resources on oral delivery development as well as its other development programs.
Vaxil’s strategy remains focused on delivering long-term value based on the unique benefits of SP's including their broad and robust immune response, both cellular and humoral, their reduced sensitivity to genetic mutation and manufacturing efficiency, especially in oncology. To that end, the Company continues to strengthen the value proposition of SPs across these therapeutic areas, by demonstrating the ability to generate a robust and consistent immune response.
Vaxil has the financial means to pursue these current programs with existing capital. In the future, additional financing may be required.
ABOUT VAXIL
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Vaxil is an Israeli immunotherapy biotech company focused on its novel approach to targeting prominent cancer markers and infectious diseases. Its lead product ImMucin™ successfully completed a Phase 1/2 clinical trial in multiple myeloma for which it received orphan drug status from the FDA and EMA. The company aims to continue to develop ImMucin™, a COVID-19 and a tuberculosis vaccine / treatment that has demonstrated promising preliminary results with further preclinical evaluation planned. Additional indications and mAb candidates are under evaluation as immuno-oncology and infectious disease treatments alone and in combination with other treatments.
Vaxil exploits the unique properties of signal peptide domains on crucial proteins to develop targeted therapies against cancer targets and infectious disease pathogens. These signal peptide domains are identified by VaxHit™, Vaxil’s proprietary bioinformatic approach. These signal peptides induce a robust T- and B-cell response across wide and varied HLA subtypes, while acting as true, universal neoantigens. The peptide platform targets these cells by “educating” or specifically activating the immune system to recognize and attack the affected cells. In addition, Vaxil’s mAb platform directly recognizes the target protein expressed on malignant cells and recruits other elements of the immune system to lyse those cells.
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Disclaimer: The Company cautions that
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