On September 19, 2022, Tricida, Inc. (Tricida) and Patheon Austria GmbH & Co KG (Patheon) entered into an amendment (Amendment No. 4), effective as of September 15, 2022, which amends certain terms of the Manufacturing and Commercial Supply Agreement, effective October 4, 2019 (as amended by amendment no. 1 dated March 30, 2021, amendment no.

2 dated August 26, 2021 and amendment no. 3 dated July 1, 2022, collectively the Agreement), between Tricida and Patheon. Pursuant to Amendment No.

4, the parties have agreed to utilize the current, ongoing manufacturing campaign window to pursue validation and implementation of a second-generation manufacturing process. The amendment provides a payment structure that does not affect the total maximum amount payable to Patheon for the manufacturing campaign, which remains capped. There is no other material modification to the Agreement, including the recently executed amendment no.

3.