On March 29, 2021, Frank P. Muscolo, the controller and principal accounting officer of Trevi Therapeutics, Inc., and the company agreed that, in connection with the hiring of Christopher Galletta to serve as the company’s controller, Mr. Muscolo would cease to serve as the company’s principal accounting officer, effective upon April 12, 2021, Mr. Galletta’s start date with the company. Mr. Galletta was hired in anticipation of Mr. Muscolo’s planned retirement in early 2022. Mr. Muscolo will continue as an employee of the company until his retirement date. Upon his start date of April 12, 2021, Mr. Galletta will serve as the Company’s principal accounting officer. Mr. Galletta, 43, served as Director of Financial Reporting at SS&C Technologies Holdings, Inc., a publicly-traded global financial services and software company, from July 2016 until March 2021, and as Assistant Vice President, Corporate Accounting at Virtus Investment Partners, Inc., a publicly-traded investment management company, from October 2011 to July 2016.