TherapeuticsMD, Inc. announced that it received approval to begin screening and enrolling subjects at its fiftieth site, the University of Florida College of Medicine, in the Company's REPLENISH Trial, a phase 3, double-blind, placebo-controlled clinical trial designed to measure the safety and effectiveness of TX 12-001HR, the Company's bio-identical combination 17ß-estradiol and progesterone drug candidate, in treating the symptoms of menopause.