Item 5.02 Departure of Directors or Certain Officers; Election of Directors;

Appointment of Certain Officers; Compensatory Arrangements of Certain

Officers.

On December 16, 2021, Joel Lebowitz notified Schrödinger, Inc. (the "Company") of his decision to retire as Chief Financial Officer of the Company, effective as of February 28, 2022.

On December 18, 2021, the Board of Directors of the Company appointed Jenny Herman as the interim principal financial officer, effective as of March 1, 2022.

Ms. Herman, age 45, has served as the Company's Senior Vice President, Finance and Corporate Controller since October 2020. Ms. Herman served as the Company's Vice President, Finance and Corporate Controller from May 2019 to October 2020, as the Company's Controller from January 2010 to May 2019, as the Company's Accounting Manager from January 2007 to January 2010, as the Company's Senior Accountant from January 2004 to January 2007 and as the Company's Staff Accountant from May 2002 to January 2004. Prior to joining the Company, Ms. Herman served as a Senior Accountant at NYK Logistics (North America), a shipping and logistics company, from September 1998 to March 2002. Ms. Herman is a certified public accountant. Ms. Herman received a B.S. in Accounting and Finance from The University of Montana - College of Business.

Ms. Herman does not have a family relationship with any of the Company's officers or directors and has no direct or indirect interest in any transaction required to be disclosed pursuant to Item 404(a) of Regulation S-K.

Ms. Herman will enter into the Company's standard form of indemnification agreement, a copy of which was filed as Exhibit 10.21 to the Company's Registration Statement on Form S-1 (File No. 333-235890) filed with the Securities and Exchange Commission on January 10, 2020, which will become effective upon the effective date of her appointment. Pursuant to the terms of the indemnification agreement, the Company may be required, among other things, to indemnify Ms. Herman for certain expenses, including attorneys' fees, judgments, fines and settlement amounts incurred by her in any action or proceeding arising out of her service as an officer of the Company.

There have been no other changes to Ms. Herman's compensatory plans or arrangements in connection with her appointment described herein.


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