SAB Biotherapeutics announced SAB-142 is being progressed as a therapeutic agent to prevent and/or delay onset and progression of Type 1 diabetes (T1D) and potentially other T-cell mediated autoimmune diseases. In an IND-enabling GLP study, SAB-142 will be compared to an FDA-approved T-cell depleting therapeutic, to assess toxicity and pharmacodynamic effects. Because SAB-142 is a fully-human polyclonal antibody, it is expected to be much less immunogenic, safer, and more effective in preventing and/or delaying onset and progression of T1D as compared to other commercially available products such as fully-animal antibodies and other monoclonal lymphodepletion therapeutics.

SAB-142 is fully-human therapeutic that may be administered multiple times without inducing immune-mediated reactions including immediate anaphylaxis or delayed serum sickness. In the GLP toxicology study, conducted in an appropriate model, SAB-142 will be dosed at 1, 5, and 10 mg/kg and commercially available anti-thymocyte globulin will be dosed at 5 mg/kg. The study is expected to be completed in the first quarter of 2023.