“The unique properties of epigenomic controllers, which are designed to have transient residence in the body while imparting durable epigenetic changes, make them well suited for use in combination treatment strategies due to their inherently orthogonal mechanism of action,” said
Key Findings:
- Analysis of biopsy data from NSCLC patients treated with anti-PD1 or EGFR inhibitors found that high MYC mRNA levels correlated with a shorter time to disease progression, establishing a rationale to evaluate MYC-targeting epigenomic controllers in a combination treatment setting.
- Combination of a MYC-targeting epigenomic controller (MYC-EC) with immune checkpoint or EGFR inhibitor enhanced anti-tumor activity.
- Treatment with a MYC-EC plus an anti-PD-L1 antibody resulted in enhanced anti-tumor activity in a syngeneic mouse model of NSCLC.
- Combination of MYC-EC with EGFR inhibitor, osimertinib, synergistically reduced tumor cell viability in vitro and significantly inhibited tumor growth in vivo in a human xenograft model of NSCLC.
The poster can be viewed on the Omega website at https://omegatherapeutics.com/science/publications/
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Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including without limitation statements regarding the future use of epigenomic controllers in combination treatment strategies; potential of the OMEGA platform to pre-transcriptionally modulate gene expression and revolutionize genomic medicine; expectations surrounding the potential of our product candidates, including OTX 2101; and expectations regarding our pipeline, including trial design, initiation of preclinical studies and advancement of multiple preclinical development programs in oncology, immunology, regenerative medicine, and select monogenic diseases. These statements are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including, but not limited to, the following: the novel technology on which our product candidates are based makes it difficult to predict the time and cost of preclinical and clinical development and subsequently obtaining regulatory approval, if at all; the substantial development and regulatory risks associated with epigenomic controllers due to the novel and unprecedented nature of this new category of medicines; our limited operating history; the incurrence of significant losses and the fact that we expect to continue to incur significant additional losses for the foreseeable future; our need for substantial additional financing; our investments in research and development efforts that further enhance the OMEGA platform, and their impact on our results; uncertainty regarding preclinical development, especially for a new class of medicines such as epigenomic controllers; potential delays in and unforeseen costs arising from our clinical trials; the fact that our product candidates may be associated with serious adverse events, undesirable side effects or have other properties that could halt their regulatory development, prevent their regulatory approval, limit their commercial potential, or result in significant negative consequences; the impact of increased demand for the manufacture of mRNA and LNP based vaccines to treat COVID-19 on our development plans; difficulties manufacturing the novel technology on which our OEC candidates are based; our ability to adapt to rapid and significant technological change; our reliance on third parties for the manufacture of materials; our ability to successfully acquire and establish our own manufacturing facilities and infrastructure; our reliance on a limited number of suppliers for lipid excipients used in our product candidates; our ability to advance our product candidates to clinical development; and our ability to obtain, maintain, enforce and adequately protect our intellectual property rights. These and other important factors discussed under the caption “Risk Factors” in our Quarterly Report on Form 10-Q for the quarter ended
Contact Investor contact:Eva Stroynowski 617.949.4370 estroynowski@omegatx.com Media contact:Jason Braco LifeSci Communications 646.751.4361 jbraco@lifescicomms.com
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