- TMP-301 (formerly HTL0014242) is a potent, selective, and orally available mGluR5 negative allosteric modulator (NAM) candidate discovered by Sosei Heptares and out-licensed to Tempero Bio
- Phase 1 study in healthy volunteers expected to begin in Q1 2023 with support from a
US$5.3M grant from theUS National Institute on Drug Abuse (NIDA) - Tempero Bio was created by Aditum Bio in collaboration with Sosei Heptares in 2020 to advance the clinical development of mGluR5 NAM candidates to develop therapies targeting substance use disorders and anxiety
- Sosei Heptares holds a strategic equity stake in Tempero Bio and retains an economic interest in TMP-301 and other compounds in the mGluR5 NAM program out-licensed to Tempero Bio
Tempero Bio was created in 2020 by the venture firm Aditum Bio (established by industry veterans
Under the terms of the agreement, Tempero Bio acquired exclusive global rights to Sosei Heptares’ portfolio of mGluR5 NAM candidates. In return, Sosei Heptares received a strategic equity stake in Tempero Bio and is eligible to receive future success-based development and commercial milestone payments plus tiered royalties from any future product sales.
The regulatory milestone achieved as noted in this announcement does not trigger a payment from Tempero Bio to Sosei Heptares.
About Sosei Heptares
We are an international biopharmaceutical group focused on the discovery and early development of new medicines originating from our proprietary GPCR-targeted StaR® technology and structure-based drug design platform capabilities. We are advancing a broad and deep pipeline of novel medicines across multiple therapeutic areas, including neurology, immunology, gastroenterology, and inflammatory diseases.
We have established partnerships with some of the world’s leading pharmaceutical companies and multiple emerging technology companies, including AbbVie, AstraZeneca,
“Sosei Heptares” is the corporate brand and trademark of
For more information, please visit https://soseiheptares.com/
LinkedIn: @soseiheptaresco |
Enquiries:
Sosei Heptares – Media and Investor Relations
Hironoshin Nomura, Chief Financial Officer
Shinichiro Nishishita, VP Investor Relations, Head of Regulatory Disclosures
+44 (0)203 928 6900 | SoseiHeptares@medistrava.com
Forward-looking statements
This press release contains forward-looking statements, including statements about the discovery, development, and commercialization of products. Various risks may cause Sosei Group Corporation’s actual results to differ materially from those expressed or implied by the forward-looking statements, including: adverse results in clinical development programs; failure to obtain patent protection for inventions; commercial limitations imposed by patents owned or controlled by third parties; dependence upon strategic alliance partners to develop and commercialize products and services; difficulties or delays in obtaining regulatory approvals to market products and services resulting from development efforts; the requirement for substantial funding to conduct research and development and to expand commercialization activities; and product initiatives by competitors. As a result of these factors, prospective investors are cautioned not to rely on any forward-looking statements. We disclaim any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.
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