Orocidin’s preclinical product is called QR-01 and has a novel mode of action. It will be the first ever medical treatment of periodontitis reaching the dental market.
The main problem with periodontitis is to treat bacterial infection as well as normalize the immunological function. This concern has highlighted the pressing need for the development of new treatment modalities.
OR-01 is specifically designed to treat the key challenge of treating periodontitis and belongs to a unique class of host defense peptides characterized by functions such as antimicrobial, and immunomodulatory roles.
Orocidin plans to initiate clinical trials for QR-01 starting Q4, 2024.
In addition to antimicrobial activity, QR-01 also participates in the activation of specific immune responses in patients. Apart from antimicrobial activity, QR-01 exerts its protective effects by its antibiofilm activities, a large problem in periodontitis and also drives the progression of the disorder.
The active ingredient is formulated in a specially developed gel formulation that is thermosensitive. This means that it is a water-like formulation at room temperature but becomes solid at mouth temperature. In the solid form it will stay in the mouth cavity for 3-4 days and the dentist can therefore easily administer the product on a bi-weekly basis
Thus, QR-01 is a key product in restraining the progression of periodontitis and treating all symptoms.
About Periodontitis
Periodontitis, a type of gum disease, is severe inflammation of the gums, with symptoms that include red, bleeding or swollen gums. It is also a bacterial infection that starts by inflaming the soft tissues around the teeth. Left untreated, it erodes the bone that supports the teeth, leading to mobility and tooth loss.
It is the main cause of tooth loss and is considered one of the two biggest threats to the oral health. Periodontitis affects more than 47% of adults over the age of 30 in the
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