TM
Biology-driven discovery. Life-changing medicines.
Corporate Overview
January 2022
NASDAQ: NGM
©2022 NGM Bio
Safe Harbor Statement
The following presentation contains forward-looking statements, including, but not limited to, statements regarding potential indications for, planned and continued development of, and therapeutic potential of, product candidates in NGM Bio's pipeline, including NGM120, NGM707, NGM831, NGM438, NGM621, MK-3655 and aldafermin; the planned timing of initiation, enrollment, data readouts and results of NGM Bio's clinical trials, including with respect to topline data for NGM621; potential future late-stage development of product candidates in NGM Bio's pipeline, including NGM621 and aldafermin; the potential activity, complementarity, safety, tolerability and efficacy of NGM's product candidates, including the potential of NGM Bio's oncology product candidates to become next- generation treatment options; NGM Bio's belief that myeloid cell reprogramming can be an important additional approach to augment anti-tumor immunity and that its portfolio of product candidates provide multiple opportunities to harness that biology; the design of NGM Bio's and Merck's clinical trials of NGM's product candidates; the preliminary findings in the Phase 1a/1b study of NGM120 providing encouraging initial signals of anti-cancer activity; the preliminary findings in the Phase 1a study of NGM707 and anticipated timing thereof; the availability and anticipated timing of topline data from Phase 2 CATALINA study of NGM621 in patients with geographic atrophy; the continuation of the Phase 2b ALPINE 4 trial of aldafermin; potential activities under NGM's amended collaboration with Merck and the potential receipt of milestone and royalty payments by NGM under the amended collaboration with Merck; the potential roles of regulating the GDF15/GFRAL pathway and ILT2, ILT4, ILT3 and LAIR1 in cancer, the powerful biology of the GDF15 pathway, the potential consequences of ILT2, ILT4, ILT3 and LAIR1 blockade and the opportunity for next generation myeloid checkpoint inhibitors to address limitations of existing immunotherapies; and the potential for NGM621 to have an opportunity for differentiation for the treatment of geographic atrophy and opportunities to achieve category leadership, and its potential for every 8-week dosing; potential option exercises by Merck under NGM Bio's amended collaboration with Merck; NGM Bio's opportunities for value creation and its ability to deliver powerful treatments; NGM Bio's strategy, including its myeloid reprogramming strategy, and potential impact of its portfolio prioritization; NGM Bio's potential near-term catalysts; and any other statements other than statements of historical facts. Because such statements deal with future events and are based on NGM Bio's current plans, objectives, estimates and expectations, they are subject to various significant risks and uncertainties and actual results, performance and achievements and the timing of events could differ materially from those described in or implied by the statements herein. Such risks and uncertainties include, without limitation, those associated with the costly and time-consuming pharmaceutical product development process and the uncertainty of clinical success, including risks related to failure or delays in successfully initiating, enrolling or completing clinical studies, the risk that NGM Bio's ongoing or future clinical studies in humans may show that NGM Bio's product candidates are not tolerable or effective treatments, the risk that preclinical studies or modeling may not be indicative of results in future human clinical trials, the risk that preliminary results from clinical studies may not be predictive of the final results of such studies, the risk that success in earlier-stage clinical studies does not ensure that later clinical trials evaluating NGM Bio's product candidates will generate the same results or otherwise provide adequate data to demonstrate the effectiveness and safety of such product candidates, and the risk that others may discover, develop or commercialize products before or more successfully than NGM Bio, including in NASH and/or geographic atrophy (GA); the ongoing COVID-19 pandemic which has adversely affected, and could materially and adversely affect in the future, NGM Bio's business and operations, including NGM Bio's ability to timely supply, initiate, enroll and complete its ongoing and future clinical trials; the time-consuming and uncertain regulatory approval process, including the risk that NGM Bio or Merck, as applicable, may not receive marketing approvals for any of NGM Bio's product candidates in a timely manner, or at all; seeking and maintaining protection of intellectual property; NGM Bio's reliance on third party manufacturers and delays or problems in the manufacture or testing of product candidates; NGM Bio's dependence on its amended collaboration with Merck for the development and potential commercialization of product candidates falling within the scope of the amended collaboration and its ability to maintain the amended collaboration, including the risk that if Merck were to breach or terminate the amended collaboration or Merck's development funding obligations thereunder, NGM Bio would not obtain all of the anticipated financial and other benefits of the amended collaboration, and the development and/or commercialization of NGM Bio's product candidates falling within the scope of the amended collaboration could be delayed, perhaps substantially; the sufficiency of NGM Bio's cash resources, including to fund development programs that fall outside of the narrower scope of NGM Bio's amended collaboration with Merck, and need for additional capital; and other risks and uncertainties affecting NGM Bio and its research and development programs, including those described under the caption "Risk Factors" and elsewhere in NGM Bio's quarterly report on Form 10-Q for the quarter ended September 30, 2021 filed with the United States Securities and Exchange Commission (SEC) on November 4, 2021 and future filings and reports of NGM Bio with the SEC. The forward-looking statements contained in the following presentation are made only as of the date hereof or as of the dates indicated in the forward-looking statements, even if they are subsequently made available by NGM Bio on its website or otherwise. NGM Bio undertakes no obligation to update or supplement any forward-looking statements after the date hereof, or to update the reasons why actual results may differ or differ materially from those anticipated in the forward-looking statements.
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Looking Forward to Multiple Program Milestones in 2022
Program | Mechanism | Status | Anticipated Milestones |
NGM621 | Anti-Complement | Ph2 CATALINA trial fully enrolled | Topline Ph2 CATALINA data readout in 4Q22 |
Geographic Atrophy | C3 Antibody | ||
NGM707
Advanced Solid Tumors
NGM831
Advanced Solid Tumors
NGM438
Advanced Solid Tumors
NGM120
Cancer and Cachexia
Aldafermin
Cirrhotic NASH
MK-3655
Non-cirrhotic NASH
ILT2/ILT4 Dual
Antagonist Antibody
ILT3 Antagonist Antibody
LAIR1 Antagonist
Antibody
GFRAL Antagonist Antibody
FGF19 Analog
FGFR1c/KLB
Agonist Antibody
Ph1/2 trial enrolling
Preclinical
Preclinical
Ph2 trial enrolling
Ph1a/1b trial ongoing
Ph2b ALPINE 4 trial enrolling
Merck-led global Ph2b trial enrolling
Initial Ph1a clinical data readout in 2H22
Initiation of Ph1 trial in 1Q22
Initiation of Ph1 trial in 2Q22
Additional Ph1a/1b clinical data readouts in 2H22
Last Patient In (LPI) in 1Q22
Ongoing enrollment
3
Our Approach Integrates Biology and Protein Engineering Expertise into the Drug Discovery and Development Process
PROTEIN | EXPANSIVE PIPELINE |
ENGINEERING | |
3 Therapeutic Areas |
Delivering powerful therapies
7
5
4
Disclosed Programs
Programs in Clinical Development
Ph2/Ph2b Studies Ongoing
EXPERIMENTAL
BIOLOGY
4
Reproducible Drug Discovery Process Has Been Applied Successfully Across Biological Frontiers
EXPERIMENTAL BIOLOGY | 7 | Disclosed Programs |
High-throughput | Receptor-ligand | NGM |
deorphanization | ||
in vivo screening | 707 | |
Human | NGM | |
genetics / systems | ||
438 | ||
biology | ||
DeliveringNGM
powerful831 therapies
NGM
120
Multi-format | Antibody | NGM |
engineering | ||
biologics | 621 | |
capabilities |
Aldafermin
MK
3655
PROTEIN ENGINEERING
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NGM Biopharmaceuticals Inc. published this content on 10 January 2022 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 10 January 2022 14:07:04 UTC.