“The data presented at DDW continue to refine and reinforce our understanding of the pharmacokinetic-pharmacodynamic relationship of α4β7 inhibition with respect to cellular biomarkers and MORF-057’s translation to treatment of patients. Further, these results link Morphic’s small molecule α4β7 inhibitors with the pharmacology associated with approved anti-integrin IBD treatments,” commented
The study presented at DDW examines longitudinal changes in circulating biomarkers in nonhuman primates (NHP) infused with stepwise increasing doses of MT-105, a small-molecule, selective α4β7 integrin inhibitor tool compound with similar chemical properties to MORF-057.
Key findings from the NHP study included consistency of biomarker data when compared with previous MORF-057 results and with observations from the approved monoclonal antibody α4β7 inhibitor. α4β7 inhibition with MT-105 elicits similar changes, including α4β7 receptor occupancy and lymphocyte subset changes, to those seen in humans receiving α4β7-targeted monoclonal antibodies or Morphic’s small molecule inhibitor of α4β7, MORF-057. The tool compound also demonstrates consistency of pharmacokinetic effect between individual animals with highly similar exposure response curves measuring the memory T cell biomarker. Notably, unbiased single cell RNA sequencing (scRNAseq) of pretreatment and MT-105-treated peripheral blood mononuclear cells reveals consistent increases in circulating plasma cells and plasmablasts correlated with increasing exposure of MT-105. These data suggest that α4β7 inhibition with MT-105 impacts antibody secretion related to gut inflammation.
Poster Sa1761: Predictive Translational Blood Biomarkers Dynamics of small molecule A4B7 inhibition in Nonhuman Primate
Authors:
Poster: DDW poster Sa176 is available on the Investors tab of Morphic’s website.
About
Morphic Therapeutic is a biopharmaceutical company developing a portfolio of oral integrin therapies for the treatment of serious chronic diseases, including autoimmune, cardiovascular, and metabolic diseases, fibrosis, and cancer.
Forward Looking Statements
This press release contains “forward-looking” statements within the meaning of the Securities Act of 1933, as amended, the Securities Exchange Act of 1934, as amended, and of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to the MInT technology platform’s ability to discover drug candidates and the ability of MORF-057 and α4β7 inhibitors to treat IBD, including ulcerative colitis, or related indications. Statements including words such as “believe,” “plan,” “continue,” “expect,” “will be,” “develop,” “signal,” “potential,” “anticipate” or “ongoing” and statements in the future tense are forward-looking statements. These forward-looking statements involve risks and uncertainties, as well as assumptions, which, if they do not fully materialize or prove incorrect, could cause our results to differ materially from those expressed or implied by such forward-looking statements. Forward-looking statements are subject to risks and uncertainties that may cause Morphic’s actual activities or results to differ significantly from those expressed in any forward-looking statement, including risks and uncertainties disclosed in this press release and other risks set forth in our filings with the
Contacts
Morphic Therapeutic
chris.erdman@morphictx.com
617.686.1718
Source: Morphic Therapeutic
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