LIXTE Biotechnology Holdings, Inc. announced that a recently published article in the journal Cancer Research showed that PP2A, the pharmacologic target of LIXTE's lead clinical compound, LB-100, when inactivated in pre-clinical models of glioma, activates a complex intracellular signaling system, the cGAS-STING pathway. This leads to an activation of interferon signaling, an increase in MHC class I expression on tumor cells, an increase in CD8(+) killer T cell proliferation, while at the same time reducing immunosuppressive tumor associated macrophages. Consequently, as shown in the article, PP2A inactivation sensitized the immunologically "cold" glioblastoma cells to immune checkpoint blockade therapy in vitro.

The May 23, 2023 article in the journal Cancer Research, entitled "PP2Ac Deficiency Enhances Tumor Immunogenicity by Activating STING-Type I Interferon Signaling in Glioblastoma," by Mondal et al. from the Department of Neurological Surgery, University of California, San Francisco.