KIND-030, a monoclonal antibody targeting canine parvovirus (CPV), is partnered with
In this randomized, blinded, placebo-controlled study, KIND-030 was administered to dogs after they tested positive for CPV infection. The primary endpoint of the study was met. The parvovirus challenge resulted in 57% mortality rate in the control dogs compared to 0% mortality rate in the KIND-030 treated dogs. The dogs did not receive any supportive care or other treatments.
'Parvovirus is a devastating disease currently without any available treatment,' said KindredBio's Chief Executive Officer,
'We are excited to partner with KindredBio on this revolutionary treatment that can significantly improve the health and well-being of dogs,' said
With this positive study, KIND-030 has now demonstrated efficacy in both indications being pursued: prophylactic therapy to prevent clinical signs of canine parvovirus infection, and treatment of established parvovirus infection. Results from the pivotal efficacy study for the therapeutic claim are expected to be submitted to the
CPV is the most significant and contagious viral cause of enteritis in dogs, especially puppies, with mortality rates as high as 91% if untreated. There are currently no
Canine parvovirus is most often seen in puppies less than 6 months of age, but can occur in unvaccinated dogs of any age. Clinical signs often include depression, not eating, vomiting, and profuse diarrhea which is often blood tinged[1]. Banfield estimates that there are approximately 250,000 parvo cases in the
KIND-030 binds to critical portions of the virus, preventing the virus from entering into cells.
On
Regulatory approval and review timeline are subject to the typical risks inherent in such a process. The results of the pivotal efficacy study for the therapeutic claim stated in this press release have not been reviewed by the
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