Item 1.01 Entry into a Material Definitive Agreement.

On June 1, 2020, Kaleido Biosciences, Inc., a Delaware corporation (the "Company"), entered into an Underwriting Agreement (the "Underwriting Agreement") with Morgan Stanley & Co. LLC, as representative of the several underwriters listed therein (the "Underwriters"), in connection with its previously announced public offering (the "Offering"), pursuant to which the Underwriters agreed to purchase 4,750,000 shares (the "Shares") of the Company's common stock, $0.001 par value per share (the "Common Stock"), at a price of $7.50 per share, less underwriting discounts and commissions.

Pursuant to the terms of the Underwriting Agreement, the Company also granted the Underwriters an option exercisable for 30 days to purchase up to an additional 712,500 shares of Common Stock at the same price per share as the Shares, less underwriting discounts and commissions. The Offering closed on June 4, 2020 and the Company received net proceeds from the sale of the Shares, after deducting underwriting discounts and commissions and other estimated offering expenses payable by the Company, of approximately $33.1 million.

The Company intends to use the net proceeds from this offering (i) to fund the Company's continued research and development activities, including the ongoing clinical program of KB109 in patients with mild-to-moderate COVID-19, the ongoing Phase 2 clinical trial of KB195 in patients with urea cycle disorders, and the planned clinical study of KB295 in patients with mild-to-moderate ulcerative colitis, (ii) to fund any other research and development activities that relate to the Company's current and future clinical and preclinical activities, and (iii) the remainder for planned general and administrative expenses, working capital and other general corporate purposes.

The Underwriting Agreement includes customary representations, warranties and covenants by the Company and customary conditions to closing, obligations of the parties and termination provisions. Additionally, under the terms of the Underwriting Agreement, the Company has agreed to indemnify the Underwriters against certain liabilities, including liabilities under the Securities Act of 1933, as amended, or to contribute to payments the Underwriters may be required to make in respect of these liabilities.

Pursuant to the Underwriting Agreement, the Company, its directors and officers and certain of its stockholders have agreed not to sell or otherwise dispose of any common stock held by us or them for a period ending 90 days after the date of the Underwriting Agreement without first obtaining the written consent of the representative of the underwriters, subject to certain exceptions.

The Offering was made pursuant to the Company's effective shelf registration statement on Form S-3 (File No. 333-236804), including the prospectus dated March 10, 2020, as supplemented by a prospectus supplement dated June 1, 2020.

The Underwriting Agreement is attached hereto as an exhibit to provide interested persons with information regarding its terms, but is not intended to provide any other factual information about the Company. The representations, warranties and covenants contained in the Underwriting Agreement were made only for purposes of the Underwriting Agreement as of specific dates indicated therein, were solely for the benefit of the parties to the

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agreement, and may be subject to limitations agreed upon by the parties, including being qualified by confidential disclosures exchanged between the parties in connection with the execution of the Underwriting Agreement.

The foregoing is only a brief description of the terms of the Underwriting Agreement, does not purport to be a complete description of the rights and obligations of the parties thereunder, and is qualified in its entirety by reference to the Underwriting Agreement that is filed as Exhibit 1.1 to this Current Report on Form 8-Kand incorporated by reference herein.

The legal opinion of Goodwin Procter LLP relating to the legality of the issuance and sale of the shares in the Offering is attached as Exhibit 5.1 to this Current Report on Form 8-K.

Item 8.01 Other Events.

On June 1, 2020, the Company issued press releases announcing the launch and pricing of the Offering. Copies of these press releases are attached hereto as Exhibits 99.1 and 99.2, respectively, and are each incorporated herein by reference.





Item 9.01 Exhibits




1.1       Underwriting Agreement, dated June 1, 2020, by and between Kaleido
        Biosciences, Inc. and Morgan Stanley & Co. LLC.

5.1       Opinion of Goodwin Procter LLP

23.1      Consent of Goodwin Procter LLP (included in Exhibit 5.1)

99.1      Press Release issued by the Company on June 1, 2020 (announcing the
        launch of the Offering)

99.2      Press Release issued by the Company on June 1, 2020 (announcing the
        pricing of the Offering)

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