France - OSE Immunotherapeutics SA (ISIN: FR0012127173; Mnemo: OSE) today announced that the Board of Directors, upon the proposal of the Nomination and Remuneration Committee, has proposed Eric Leire, MD, as an independent Director of the Company.

This appointment reflects the Company's willingness to enlarge the Board's skills and expertise and to strengthen its international scope to support its growth.

Moreover, the Board of Directors proposes the appointment of Nicolas Poirier, Chief Executive Officer of OSE Immunotherapeutics, as director and of Anne-Laure Autret-Cornet, Chief Financial Officer, as director representing the employee shareholders who voted in her favor. The renewal of the term of office of Pr. Brigitte Dreno and Pr. Gerard Tobelem as independent directors is also proposed.

Eric Leire brings a professional international experience, both in the US and in Europe, in biotechnology and in the pharmaceutical industry. He is currently President and Chief Executive Officer of Genflow Biosciences Ltd (listed on LSE: GENF / gene therapy, senescence domain). Previously, he was Chairman and President and Chief Executive Officer of two companies in the US: Enochian Biosciences (listed on Nasdaq ENOB / cell and gene therapy, VIH and cancer) and DanDrit Biotech (listed on OTCQB). He formerly held the position of Marketing manager in the pharmaceutical industry in the US and in Europe (Pfizer, Schering Plough, Boots Pharma). Through his active experience in venture capital funds in the health field at Medwell Capital (Canada) and Biofund Venture (Denmark), he has developed biotech companies financed by investment funds.

Eric Leire is a Medical Doctor (Grenoble University), holder of a postgraduate diploma (DESS) in Health law (Sceaux University). He spent 3 years as a researcher at the Harvard AIDS Institute. He holds an MBA from HEC (ISA) and from Kellogg Graduate School of Management (Chicago). Eric Leire is American and French citizen.

ABOUT OSE Immunotherapeutics

OSE Immunotherapeutics is a biotech company dedicated to developing first-in-class assets in immuno-oncology and immuno-inflammation. The Company's current well-balanced first-in-class clinical pipeline includes: Tedopi (immunotherapy activating tumor specific T-cells, off-the-shelf, neoepitope-based): this cancer vaccine is the Company's most advanced product; positive results from the Phase 3 trial (Atalante 1) in Non-Small Cell Lung Cancer patients in secondary resistance after checkpoint inhibitor failure. Other Phase 2 trials, sponsored by clinical oncology groups, of Tedopi in combination are ongoing in solid tumors. OSE-279 (anti-PD1): ongoing Phase 1/2 in solid tumors or lymphomas (first patient included). OSE-279 is the backbone therapy of the BiCKI platform. OSE-127 - lusvertikimab (humanized monoclonal antibody antagonist of IL-7 receptor); ongoing Phase 2 in Ulcerative Colitis (sponsor OSE Immunotherapeutics); ongoing preclinical research in leukemia (OSE Immunotherapeutics). FR-104/VEL-101 (anti-CD28 monoclonal antibody): developed in partnership with Veloxis Pharmaceuticals, Inc. in transplantation; ongoing Phase 1/2 in renal transplant (sponsor Nantes University Hospital); Phase 1 ongoing in the US (sponsor Veloxis Pharmaceuticals, Inc.). OSE-172/BI 765063 (anti-SIRP monoclonal antibody on CD47/SIRP pathway) developed in partnership with Boehringer Ingelheim in advanced solid tumors; positive Phase 1 dose escalation results in monotherapy and in combination, in particular with anti-PD-1 antibody ezabenlimab; international Phase 1b ongoing clinical trial in combination with ezabenlimab alone or with other drugs in patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) and hepatocellular carcinoma (HCC).

Contact:

Nicolas Poirier

Email: nicolas.poirier@ose-immuno.com

Tel: +33 6 68 08 85 68

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