Item 7.01 Regulation FD Disclosure

On January 11, 2022, Cardiff Oncology, Inc. (the "Company") issued a press release announcing announced new data from its lead clinical program evaluating onvansertib in combination with standard-of-care (SOC) FOLFIRI/bevacizumab for second-line treatment of patients with KRAS-mutated metastatic colorectal cancer (mCRC). The data will be presented as a poster by Dr. Heinz-Josef Lenz, principal investigator, USC Norris Comprehensive Cancer Center, at the American Society of Clinical Oncology Gastrointestinal Cancers Symposium (ASCO-GI) on Saturday, January 22, 2022. A copy of the press release is furnished as Exhibit 99.1 to this Form 8-K. In addition, the Company plans to make a presentation to investors at 5:00 pm ET on January 18, 2022 with the Corporate Presentation furnished as Exhibit 99.2 to this Form 8-K.

In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K is being furnished and shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities of that Section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended.

Item 9.01. Financial Statements and Exhibits

(d) Exhibits.

99.1 Press Release of Cardiff Oncology, Inc. dated January 18, 2022

99.2 Corporate Presentation dated January 18, 2022

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