In a new article published in Frontiers in Veterinary Science, the company
For
The results of the clinical trial demonstrate that more information than just affinity is necessary to select the optimal antibodies. A decisive factor to ensure a good protection is through the kinetics of the association rate of the antibodies to the biomarker. In this study the rate of the detecting antibodies is 3x105 and 5x105Mol/s respectively. It is at the slow range of being strong neutralizing IgG antibodies for immunity, but sufficient in a diagnostic kit as a higher concentration of the capturing antibody can be added. This means that the antibodies, in competition with other potential binders in the blood sample, interact with the biomarker faster and thus increase sensitivity and accuracy. The slow off-rate allows detection performance to be maintained to the secondary detection antibody used in ELISA methods.
According to the article, the Alertix test, Canine TK1 ELISA, has a significantly higher ability to differentiate dogs with T-Cell lymphoma compared to dogs with B-cell lymphoma than existing TK1 tests. It shows that the Aletrix test can work both for diagnosis and monitoring of dogs with lymphoma.
In the picture, the schematical displays the specific and non-specific interactions that can come up in blood tests. It is important both for diagnostic accuracy and for good immunity that the black specific curve is significantly better than the orange non-specific curve.
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teodor.aastrup@attana.com
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https://news.cision.com/attana/r/new-publication-that-shows-the-strength-of-attana-s-offering-in-diagnostics--here-applied-in-veterin,c3842201
https://mb.cision.com/Main/16535/3842201/2319683.pdf
https://news.cision.com/attana/i/immunity,c3219591
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