- New research collaboration will explore the differentiation of eblasakimab's mechanism of action versus biologic therapies for atopic dermatitis (AD), dupilumab and lebrikizumab.
- The findings will deepen understanding of the biology underlying the recent finding that some AD patients may respond to eblasakimab even after having an inadequate response to dupilumab.
- The first part of the collaboration will focus on receptor biology and kinetics to investigate the cellular and molecular basis of eblasakimab’s potential for differentiation. This work will be funded by Zenyaku.
In previously published translational data1 from immune cells and skin biopsies of AD patients, blocking the IL-13 receptor (IL-13R) with eblasakimab appeared to be more effective at downregulating inflammatory markers than blocking the IL-4 receptor (IL-4R), the target of dupilumab, suggesting eblasakimab has the potential to be more efficient in blockade of Type 2 receptor signaling than dupilumab. Under the new research collaboration, ASLAN and Zenyaku will conduct collaborative studies that will explore the biology of the IL-13 and IL-4 receptors, including the effects of biologics eblasakimab, dupilumab and lebrikizumab on each receptor subunit.
The results from this research collaboration will provide further insight into the differentiated receptor biology of targeting IL-13R versus IL-4R. The studies may also explain the long-lasting inhibition of disease severity biomarkers, such as TARC, observed after the end of the eblasakimab treatment period in earlier clinical studies2. This new agreement expands upon the commercial agreement that ASLAN signed with Zenyaku in
“Eblasakimab could be an important new treatment for the growing number of AD patients and we are pleased to expand our collaboration with ASLAN to learn more about the scientific principles underlying eblasakimab’s differentiation from other biologics by utilizing our cutting-edge research facilities. Based on the strong translational and clinical data that ASLAN has generated to date, we believe that eblasakimab has a unique mechanism of action that could provide patients with a safe, efficacious and convenient new treatment option for AD,” said
“Based on our recent positive interim data from TREK-DX, we believe eblasakimab may have the potential to be effective in AD patients with inadequate response to dupilumab and this collaboration may help us to understand the biology underlying why some patients may respond better to eblasakimab than other biologics,” said Dr
References
- Reddy et al EADV presentation
October 2023 - Cevikbas et al WCD poster presentation
July 2023
About eblasakimab
Eblasakimab is a potential first-in-class monoclonal antibody targeting the IL-13 receptor subunit of the Type 2 receptor, a key pathway driving several allergic inflammatory diseases. Eblasakimab’s unique mechanism of action enables specific blockade of the Type 2 receptor and has the potential to improve upon current biologics used to treat allergic disease. By blocking the Type 2 receptor, eblasakimab prevents signaling through both interleukin 4 (IL-4) and interleukin 13 (IL-13) – the key drivers of inflammation in AD and Type 2-driven COPD. ASLAN announced positive results from the Phase 2b TREK-AD study of eblasakimab in moderate-to-severe biologic-naïve AD patients in
About
Forward looking statements
This release contains forward-looking statements. These statements are based on the current beliefs and expectations of the management of the Company. These forward-looking statements may include, but are not limited to statements regarding the Company’s business strategy and clinical development plans; statements related to the safety and efficacy of eblasakimab, including interim results; the Company’s plans and expected timing with respect to clinical trials, clinical trial enrollment and clinical trial results for eblasakimab; and the potential of eblasakimab as a first-in-class treatment for atopic dermatitis. The Company’s estimates, projections and other forward-looking statements are based on management's current assumptions and expectations of future events and trends, which affect or may affect the Company’s business, strategy, operations, or financial performance, and inherently involve significant known and unknown risks and uncertainties. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of many risks and uncertainties, which include, unexpected safety or efficacy data observed during preclinical or clinical studies; risks that future clinical trial results may not be consistent with interim, initial or preliminary results or results from prior preclinical studies or clinical trials; clinical site activation rates or clinical trial enrollment rates that are lower than expected; the impact of health epidemics or pandemics, or geopolitical conflicts on the Company’s operations, research and development and clinical trials and potential disruption in the operations and business of third-party manufacturers, contract research organizations, other service providers and collaborators with whom the Company conducts business; general market conditions; changes in the competitive landscape; the Company’s ability to obtain and maintain intellectual property protection for product candidates; and the Company’s ability to obtain sufficient financing to fund its strategic and clinical development plans. Other factors that may cause actual results to differ from those expressed or implied in such forward-looking statements are described in the Company’s
ASLAN Media and IR contacts
Tel: +65 6206 7350 Email: ASLAN@spurwingcomms.com | Tel: +1 (617) 430-7577 Email: arr@lifesciadvisors.com |
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