Item 5.07 Submission of Matters to a Vote of Security Holders.

We held our Annual Meeting of Stockholders ("Annual Meeting") on June 24, 2022. Of the 42,301,013 shares of our common stock outstanding and entitled to vote as of May 9, 2022, 15,733,250, or 37.19%, of such shares were represented, either by attending the Annual Meeting or by proxy, constituting a quorum under our bylaws. The matters voted on at the Annual Meeting and the votes cast with respect to each such matter are set forth below.





1.  Election of Seven Directors. The following nominees were re-elected by the
    holders of our common stock to serve as directors to hold office until our
    2023 annual meeting of stockholders and until their successors have been duly
    elected and qualified:




    Nominee            For          Against       Abstain       Broker Non-Votes
Gregory D.
Gorgas               4,577,152       635,335       90,644           10,430,119
Connie Matsui        4,862,361       340,583       100,187          10,430,119
Steven Kelly         4,865,668       345,909       91,554           10,430,119
R. Martin
Emanuele, Ph.D.      4,950,274       262,171       90,686           10,430,119
Douglas Blayney,
M.D.                 4,956,842       254,605       91,684           10,430,119
Gregory R.
Reyes, M.D.,
Ph.D.                4,943,601       260,844       98,686           10,430,119
Tamara A.
Seymour              4,799,475       400,166       103,490          10,430,119




2.  Advisory Vote to Approve Named Executive Officer Compensation (the
    "Say-on-Pay Vote"). On an advisory basis, the compensation of our named
    executive officer for the year ended December 31, 2021, as disclosed in our
    proxy statement for our 2022 annual meeting of stockholders, was approved by
    our stockholders based on the following results of voting:




    For          Against       Abstain       Broker Non-Votes
  4,121,598       998,904       182,629          10,430,119




3.  Advisory Vote to Approve the Frequency of the Say-on-Pay Vote. On an advisory
    basis, frequency at which the Say-On-Pay Vote at future annual meetings of
    stockholders will be held, as disclosed in our proxy statement, was approved
    for "THREE YEARS" by our stockholders based on the following results of
    voting:




 One Year        Two Years      Three Years       Abstain
  2,234,514         76,853         2,456,016       535,748




4.  To Approve the Potential Issuance and Sale of 20% or More of the Company's
    Common Stock to Lincoln Park Capital Fund, LLC. The potential issuance and
    sale of 20% or more of the Company's Common Stock at an average price less
    than the Minimum Price pursuant to the Purchase Agreement with Lincoln Park
    Capital Fund, LLC was approved by our stockholders based on the following
    results of voting:




    For          Against       Abstain       Broker Non-Votes
  4,408,965       792,595       101,571          10,430,119




5.  Ratification of Appointment of Independent Registered Public Accounting Firm.
    The appointment of Malone Bailey LLP as our independent registered public
    accounting firm for the fiscal year ending December 31, 2022 was ratified
    based on the following results of voting:




    For           Against       Abstain      Broker Non-Votes
  15,112,289       439,441       181,520                 -





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