Auris Medical Holding AG provided an update on its intranasal betahistine development programs. In December 2018, the Company announced the acquisition of an Orphan Drug Designation for betahistine in the treatment of obesity associated with Prader-Willi syndrome (PWS). The transaction is now closed and the transfer of the designation to Auris Medical has since been recorded by the U.S. Food and Drug Administration (FDA). PWS is a rare genetic disorder characterized by progressive obesity, behavioral issues, delayed cognition and sleep disturbances. In a related transaction, the Company acquired exclusive rights to in-license two U.S. patents relating to the use of betahistine for the treatment of depression and attention-deficit /hyperactivity disorder (ADHD). This transaction is expected to close in the coming weeks. In the intranasal betahistine programs for the treatment of acute vertigo (AM-125) and for the prevention of antipsychotic-induced weight gain (AM-201), the preparations for the respective proof-of-concept trials have advanced well. In both cases, the clinical trial applications have been submitted, and the Company expects the trials to start recruitment in the first quarter of 2019. In the AM-125 program, the Phase 2 "TRAVERS" trial will enroll 138 patients suffering from acute vertigo following surgical removal of a vestibular schwannoma, a tumor growing behind the inner ear. In the AM-201 program, a Phase 1b pharmacokinetic/pharmacodynamics trial will enroll 50 healthy volunteers who will receive either AM-201 or placebo concomitantly with olanzapine over four weeks.