Achilles Therapeutics

Precision Cell Therapy Targeting All Tumor Cells

August 2023

Non-Confidential

© Achilles Therapeutics plc 2023

Forward-Looking Statements

This presentation contains "forward-looking statements," including statements regarding the proposed development plans and timelines for the Company's product candidates and the success, cost and timing of its research activities and clinical trials. Forward-looking statements can generally be identified by the use of words such as "anticipate," "believe," "continue," "could," "estimate," "expect," "forecast," "intend," "may," "plan," "project," "potential," "seek," "should," "think," "will," "would" and similar expressions, or they may use future dates.

Such forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause actual results to be materially different from any future results, performance or achievements expressed or implied by such statements. These and other risks which may impact management's expectations are described in greater detail under the heading "Risk Factors" in the Company's quarterly report or Annual Report on Form 20-F and in any subsequent periodic or current report that the Company files with the SEC.

All forward-looking statements reflect the Company's estimates only as of the date of this presentation (unless another date is indicated) and should not be relied upon as reflecting the Company's views, expectations or beliefs at any date subsequent to the date of this presentation.

Non-Confidential

© Achilles Therapeutics plc 2023

1

Working to transform the treatment of solid tumors with precision T cell therapy

Company

Nasdaq IPO:

Early clinical

Clinical

founded

ACHL

proof of concept

update

2016

2021

2022

Q4 2023

Global Headquarters

Two active clinical

U.S. Headquarters

London, UK

programs with near-term

Philadelphia, PA

clinical milestones

Emerging PoC for

cNeT in NSCLC

$144 M1 cash supports

operations through 2025

~200 employees

Non-Confidential

© Achilles Therapeutics plc 2023

1. As of June 30, 2023

2

Targeting clonal neoantigens with patented technology, linking mechanism and potency

Clonal neoantigens

Sub-clonal neoantigens

T cells

Clonal neoantigens:

a novel and ideal cancer

target

World leading, patented

capability to identify

clonal neoantigens

Clonal

neoantigens

Tumor

Quantify and

characterize tumor-

reactive T cells in the

patient

Only present on all cancer cells & absent from healthy tissue

Identifying the most

potent and immunogenic

targets

Demonstrated target

engagement supporting

mechanism of action

Non-Confidential

© Achilles Therapeutics plc 2023

3

Experienced leadership with decades in cell therapy drug development

Robert Coutts

CFO

Shree Patel

EVP, Patient Supply

Operations

Sergio Quezada

CSO

Iraj Ali

CEO

Jim Taylor

CBO

Karl Peggs

CMO

Daniel Hood

General Counsel

Ed Samuel

EVP, Technical

Operations

Non-Confidential

© Achilles Therapeutics plc 2023

4

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Achilles Therapeutics plc published this content on 04 August 2023 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 04 August 2023 11:33:05 UTC.