Spero Therapeutics, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on identifying and developing novel treatments for rare diseases and diseases caused by multi-drug resistant (MDR) bacterial infections with unmet need. Its product candidate SPR720 is an investigational, chemically stable phosphate ester prodrug that is converted in vivo to SPR719 for the treatment of nontuberculous mycobacterial (NTM) pulmonary disease. Its clinical stage product candidate, tebipenem HBr is an investigational oral carbapenem antibiotic being developed for the treatment of complicated urinary tract infections (cUTIs) including acute pyelonephritis (AP) to help patients potentially reduce duration of in-patient therapy.

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Biotechnology & Medical Research

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Quotes

Date	Price	Change	Volume
26-08-17	US$1.190	-3.25%	299,010
26-08-14	US$1.230	-0.81%	744,545
26-08-13	US$1.240	+4.20%	1,292,910
26-08-12	US$1.190	-3.25%	774,554
26-08-11	US$1.230	0.00%	364,060

Delayed Quote Nasdaq

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Sell

Buy

Mean consensus

HOLD

Number of Analysts

Last Close Price

1.230USD

Average target price

4.000USD

Spread / Average Target

+225.20%

Consensus

EPS Estimates

Revisions to estimates

Quarterly revenue - Rate of surprise

Company calendar

Market Closed - Nasdaq 16:00:00 2026-08-17 EDT			5-day change	1st Jan Change
1.190 ^USD	-3.25%		-5.56%	-48.93%

08-12	Spero Therapeutics, Inc., Q2 2026 Earnings Call, Aug 12, 2026
08-12	Spero Therapeutics, Inc. Reports Earnings Results for the Second Quarter and Six Months Ended June 30, 2026	CI

Market Cap	71.63M 61.84M 58.01M 52.84M 99.35M 6.85B 101M 680M 266M 3.43B 269M 263M 11.41B	P/E 2024	-0.81x	P/E 2025	15.5x
Enterprise Value	71.63M 61.84M 58.01M 52.84M 99.35M 6.85B 101M 680M 266M 3.43B 269M 263M 11.41B	EV / Sales 2024	1,170,430x	EV / Sales 2025	-
Free-Float	77.39%	Yield 2024 *	-	Yield 2025	-

08-12	Spero Therapeutics, Inc., Q2 2026 Earnings Call, Aug 12, 2026
08-12	Spero Therapeutics, Inc. Reports Earnings Results for the Second Quarter and Six Months Ended June 30, 2026	CI
07-27	Spero Therapeutics, Inc. Announces Appointment of Debra Jeske Zack as Chief Medical Officer	CI
07-15	Innovent Biologics Shares Surge on Spero Deal That Could Be Worth $1.1 Billion	DJ
07-14	Innovent Biologics, Inc. and Spero Therapeutics, Inc. Announce Exclusive License Agreement for IBI355, Phase 2-Ready Third-Generation Anti-CD40L Antibody	CI
07-14	Spero Therapeutics Licenses Immunology Drug Candidate From Innovent, Recieves $105 Million Financing	MT
07-14	Spero licenses Innovent's experimental immune disease drug for up to $1.1 billion	RE
06-29	Spero Therapeutics, Inc.(NasdaqGS:SPRO) added to Russell 3000E Growth Benchmark	CI
06-29	Spero Therapeutics, Inc.(NasdaqGS:SPRO) added to Russell 3000E Index	CI
06-29	Spero Therapeutics, Inc.(NasdaqGS:SPRO) added to Russell Microcap Index	CI
06-28	Spero Therapeutics, Inc.(NasdaqGS:SPRO) added to Russell Microcap Growth Benchmark Index	CI
06-17	GSK says US FDA approves urinary tract infection treatment Utebzi	AN
06-17	GSK plc Receives US FDA Approval for Oral Antibiotic Tebipenem for Complicated Urinary Tract Infections	CI

25-10-21	Spero Therapeutics, Inc. and Gsk plc Announces Efficacy and Safety Results of the Positive Pivot-Po Trial Evaluating Tebipenem Hbr	CI
24-12-20	Evercore ISI Downgrades Spero Therapeutics to In Line From Outperform, Price Target is $5	MT
24-11-18	TD Cowen Downgrades Spero Therapeutics to Hold From Buy	MT
24-08-06	TD Cowen Upgrades Spero Therapeutics to Buy From Hold	MT
23-08-14	HC Wainwright Adjusts Price Target on Spero Therapeutics to $7 From $6, Keeps Buy Rating	MT

Spero Therapeutics, Inc. Stock

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SPRO

US84833T1034

Biotechnology & Medical Research

Valuation: Spero Therapeutics, Inc.

Chart: Spero Therapeutics, Inc.

Latest news : Spero Therapeutics, Inc.

Last Transcript: Spero Therapeutics, Inc.

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Managers and Directors: Spero Therapeutics, Inc.

Latest insider transactions

Bio Therapeutic Drugs

Financials

Company Profile

Quotes

Income Statement and Estimates

Analysts' Consensus

Quarterly revenue - Rate of surprise

08-12	Spero Therapeutics Announces Second Quarter 2026 Operating Results and Provides Business Update	AQ
08-06	Spero Therapeutics : Initial Statement of Beneficial Ownership (Form 3)	PU
08-05	Spero Therapeutics Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)	AQ
08-04	Spero Therapeutics to Report Second Quarter 2026 Financial Results and Provide Business Update on August 12, 2026	AQ
07-27	Spero Therapeutics Appoints Debra Jeske Zack, M.D., Ph.D., as Chief Medical Officer	AQ

06-18	Bourse : L'Oréal met le cap sur l'Inde, gros contrat pour Alstom, rumeur sur Edenred
06-18	Star Warsh
06-18	MORNING BRIEFING - Deutschland/Europa -2-
06-17	GSK und Spero Therapeutics erhalten US-Zulassung für Utebzi
25-10-21	GSK et Spero publient des résultats positifs sur un antibiotique expérimental

1 day	-3.25%
1 week	-5.56%
Current month	+1.71%
1 month	-24.20%
3 months	-57.35%
6 months	-50.21%
Current year	-48.93%

1 week	1.18	1.3
1 month	1.08	1.57
Current year	1.08	3.08
1 year	1.08	3.08
3 years	0.51	3.22
5 years	0.51	19.87
10 years	0.51	23.64

Manager	Title	Age	Since
Esther Rajavelu CEO	Chief Executive Officer	47	2025-01-09
Debra Zack CTO	Chief Tech/Sci/R&D Officer	69	2026-07-26
Timothy Keutzer COO	Chief Operating Officer	58	2023-01-31

Director	Title	Age	Since
Milind Deshpande CHM	Chairman	69	2013-12-31
Patrick Volkert Vink BRD	Director/Board Member	62	2015-08-31
Frank Thomas CHM	Chairman	56	2025-01-09

Date	Insider	Type	Main position	Quantity	% Market Cap.
8/3/26	Debra Zack	Free	Chief Technology Officer	486,986	0.8411%
2/6/26	Esther Rajavelu	Sell	Chief Executive Officer	87,917	0.1560%
2/6/26	Timothy Keutzer	Sell	Chief Operating Officer	18,652	0.0331%

Add to a list 0 selected To use this feature you must be a member Log in Sign up	Change	5-day change	1-year change	3-year change	Capi.($)
SPERO THERAPEUTICS, INC.	-3.25%	-5.56%	-37.70%	-9.16%	71.22M
WUXI APPTEC CO., LTD.	+4.80%	+7.80%	+70.64%	+114.21%	70.07B
ARGENX SE	+17.12%	+12.05%	+54.42%	+86.20%	52.87B
INSMED INCORPORATED	+3.70%	-2.12%	+0.41%	+469.55%	27.02B
WUXI BIOLOGICS (CAYMAN) INC.	+2.26%	+0.65%	+49.19%	+10.30%	23.61B
BIONTECH SE	-1.60%	-2.21%	-19.31%	-15.15%	23.38B
PHARMAESSENTIA CORPORATION	-6.00%	+13.71%	+244.39%	+443.26%	19.43B
GENMAB A/S	+3.80%	+5.25%	+40.50%	-16.41%	18.75B
SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.	+0.38%	-3.15%	+20.39%	+589.77%	15.85B
EXELIXIS, INC.	+2.11%	-3.24%	+36.57%	+145.40%	12.7B
Average	+2.34%	-2.15%	+45.95%	+181.80%	26.38B
Weighted average by Cap.	+5.10%	-1.14%	+56.27%	+169.24%

	2024	2025
Net sales	47.98M 41.42M 38.86M 35.39M 66.55M 4.59B 67.47M 456M 178M 2.3B 180M 176M 7.64B	66.8M 57.67M 54.1M 49.28M 92.66M 6.39B 93.94M 634M 249M 3.2B 251M 245M 10.64B
Net income	-68.57M -59.19M -55.53M -50.58M -95.11M -6.56B -96.42M -651M -255M -3.28B -257M -252M -10.93B	8.57M 7.4M 6.94M 6.32M 11.89M 820M 12.05M 81.39M 31.89M 411M 32.18M 31.49M 1.37B
Net Debt	-	-