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Valuation: Silence Therapeutics plc

Market Cap 247M 327M 285M 264M 464M 30.87B 467M 3.13B 1.21B 15.19B 1.23B 1.2B 52.76B P/E 2026 *
-11.1x
P/E 2027 * -11x
Enterprise Value 94.6M 125M 109M 101M 177M 11.81B 178M 1.2B 465M 5.81B 470M 460M 20.18B EV / Sales 2026 *
33.1x
EV / Sales 2027 * -11.4x
Free-Float
69.36%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Chief Executive Officer 72 2025-12-13
Director of Finance/CFO 54 2022-02-20
Chief Tech/Sci/R&D Officer - 2020-12-31
Director TitleAgeSince
Director/Board Member 63 2018-06-20
Chairman 72 2019-11-30
Director/Board Member 54 2025-12-17
Change 5-day change 1-year change 3-year change Capi.($)
-0.93%-2.73% - - 327M
+1.44%+1.71%-10.98%-6.19% 43.13B
+3.31%+5.93%+310.97%+534.70% 34.65B
+2.84%+2.14%+9.34%+41.02% 30.03B
-1.70%-7.54%+8.43%-21.94% 28B
-1.90%-1.56%+10.24%+21.21% 24.45B
-0.14%+5.86% - - 14.34B
+0.68%-1.53%+48.76%+104.27% 13.14B
-0.57%-2.43%+5.08%+4.79% 12.53B
-0.26%+1.15%+98.13%+80.47% 12.25B
Average +0.28%+0.73%+60.00%+94.79% 23.61B
Weighted average by Cap. +0.77%+1.27%+65.47%+110.06%

Financials

2026 *2027 *
Net sales 2.86M 3.78M 3.3M 3.06M 5.37M 357M 5.4M 36.25M 14.05M 176M 14.21M 13.9M 610M 4.13M 5.46M 4.76M 4.41M 7.74M 515M 7.79M 52.32M 20.28M 254M 20.5M 20.06M 881M
Net income -49.12M -64.97M -56.65M -52.47M -92.11M -6.13B -92.67M -622M -241M -3.02B -244M -239M -10.48B -80.11M -106M -92.39M -85.57M -150M -10B -151M -1.02B -393M -4.92B -398M -389M -17.09B
Net Debt -153M -202M -176M -163M -286M -19.06B -288M -1.94B -750M -9.38B -758M -742M -32.58B -294M -389M -339M -314M -552M -36.74B -555M -3.73B -1.45B -18.08B -1.46B -1.43B -62.79B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
Employees
88
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