Valuation : Silence Therapeutics plc

Market Cap 592M 801M 689M 650M 1.11B 76.62B 1.12B 7.74B 2.98B 38.86B 3.01B 2.94B 123B P/E 2026 *
-25x
P/E 2027 * -20.1x
Enterprise Value 459M 621M 534M 504M 859M 59.4B 866M 6B 2.31B 30.13B 2.33B 2.28B 95.7B EV / Sales 2026 *
1,424x
EV / Sales 2027 * 557x
Free-Float
69.35%
Yield 2026 *
-
Yield 2027 * -

Last Transcript : Silence Therapeutics plc

Manager TitleAgeSince
Chief Executive Officer 72 2025-11-30
Director of Finance/CFO 54 2022-01-31
Chief Tech/Sci/R&D Officer - 2020-12-31
Director TitleAgeSince
Director/Board Member 63 2018-06-20
Chairman 72 2003-12-31
Director/Board Member 65 2025-05-04
Change 5-day change 1-year change 3-year change Capi.($)
-0.93%-2.73% - - 816M
-0.56%-8.08%-3.88%+10.58% 46.38B
-2.08%-3.57%+402.72%+533.09% 44.51B
+0.12%-5.27%+39.94%+20.50% 42.3B
-2.62%-5.76%+8.88%+77.44% 39.91B
-1.26%-3.37%+11.87%+40.55% 32.79B
+0.16%-3.65% - - 17.13B
-0.54%-1.72%+22.34%+115.10% 16.36B
-0.03%-3.46%+12.68%+30.90% 14.31B
-1.92%-6.94%+78.12%+36.68% 13.29B
Average -0.97%-4.30%+71.58%+108.10% 29.66B
Weighted average by Cap. -1.09%-4.54%+87.11%+129.36%

Financials

2026 *2027 *
Net sales 322K 436K 375K 354K 603K 41.7M 608K 4.22M 1.62M 21.15M 1.64M 1.6M 67.19M 751K 1.02M 873K 824K 1.4M 97.07M 1.42M 9.81M 3.78M 49.24M 3.81M 3.73M 156M
Net income -42.14M -57M -49.02M -46.25M -78.77M -5.45B -79.48M -551M -212M -2.76B -214M -209M -8.78B -71.01M -96.06M -82.61M -77.95M -133M -9.18B -134M -928M -357M -4.66B -361M -353M -14.8B
Net Debt -133M -180M -155M -146M -249M -17.21B -251M -1.74B -670M -8.73B -676M -661M -27.73B -174M -235M -202M -191M -325M -22.51B -328M -2.28B -876M -11.42B -884M -865M -36.26B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
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