![Isaac Manke](data:image/svg+xml,<svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="%231b1b1b" class="bi bi-person-fill" viewBox="0 0 16 16"><path d="M3 14s-1 0-1-1 1-4 6-4 6 3 6 4-1 1-1 1zm5-6a3 3 0 1 0 0-6 3 3 0 0 0 0 6"/></svg>)
Isaac Manke
Director/Board Member at
ADDEX THERAPEUTICS LTD
Net worth: 786 712 $ as of 2026-06-29
Profile
Isaac Manke is currently an Independent Non-Executive Director at Addex Therapeutics Ltd. since 2016.
Dr. Manke is a Director at Renovacor Holdings, Inc. Dr. Manke is a Director & Senior VP-Business Development at OnKure Therapeutics, Inc. starting in 2026.
Dr. Manke is an Independent Director at Q32 Bio, Inc. since 2024.
Former roles include Director at OnKure, Inc., Karos Pharmaceuticals, Inc., True North Therapeutics, Inc., ReViral Ltd., and Chardan Healthcare Acquisition 2 Corp.
Dr. Manke was an Associate at Deutsche Bank Securities, Inc. from 2006 to 2007.
Dr. Manke was a Research Analyst at Sanford C.
Bernstein & Co. LLC.
Dr. Manke was a General Partner at New Leaf Venture Partners LLC from 2009 to 2019.
Dr. Manke was a Senior Analyst at Health Advances LLC from 2005 to 2006.
Dr. Manke was a Partner at Acorn Capital Advisors LLC from 2020 to 2025.
Education includes a doctorate from Massachusetts Institute of Technology conferred in 2005 and an undergraduate degree from Minnesota State University Moorhead.
Known holdings in public companies
| Company | Date | Number of shares | Valuation | Valuation date |
|---|---|---|---|---|
0.32% | 2026-06-29 | 53,521 ( 0.32% ) | 681 858 $ | 2026-06-29 |
0.05% | 2026-03-31 | 20,583 ( 0.05% ) | 93 858 $ | 2026-06-29 |
| 2026-03-17 | 219,561 ( 0.1% ) | 10 996 $ | 2026-06-29 |
Isaac Manke active positions
| Companies | Position | Start |
|---|---|---|
| ADDEX THERAPEUTICS LTD | Director/Board Member | 2015-12-31 |
Renovacor Holdings, Inc.
 Renovacor Holdings, Inc. BiotechnologyHealth Technology Develops transformative gene therapy | Director/Board Member | - |
Former positions of Isaac Manke
| Companies | Position | End |
|---|---|---|
Acorn Capital Advisors LLC
 Acorn Capital Advisors LLC Investment ManagersFinance Acorn Bioventures invests in small-cap public and private companies located in the United States. The firm target companies operating in the fields of health & biotechnology sectors. It provides financing for seed, cross-over financings, IPOs, registered direct offerings and PIPEs transactions. | Private Equity Investor | 2025-06-30 |
New Leaf Venture Partners LLC
 New Leaf Venture Partners LLC Investment ManagersFinance New Leaf Ventures invests in public and private healthcare technology companies located in the US. The firm participates in early and later-stage capital requirements. | Private Equity Investor | 2019-11-30 |
Sanford C. Bernstein & Co. LLC
 Sanford C. Bernstein & Co. LLC Investment Banks/BrokersFinance Provides brokerage services | Analyst-Equity | 2008-12-30 |
Deutsche Bank Securities, Inc.
 Deutsche Bank Securities, Inc. Investment Banks/BrokersFinance Provides brokerage services | Analyst-Equity | - |
Health Advances LLC
 Health Advances LLC Pharmaceuticals: MajorHealth Technology Provides sciences strategy consulting services to life sciences companies and investors | Corporate Officer/Principal | 2005-12-31 |
Training of Isaac Manke
Experiences
Positions held
Active
Inactive
Listed companies
Private companies
Connections
80
1st degree connections
14
1st degree companies
Male
Female
Members of the board
Executives
Linked companies
| Private companies | 14 |
|---|---|
Deutsche Bank Securities, Inc.
Deutsche Bank Securities, Inc. Investment Banks/BrokersFinance Provides brokerage services | Finance |
OnKure, Inc.
 OnKure, Inc. BiotechnologyHealth Technology Operates as a biopharmaceutical company developing epigenetic therapies for the treatment of cancer | Health Technology |
Sanford C. Bernstein & Co. LLC
Sanford C. Bernstein & Co. LLC Investment Banks/BrokersFinance Provides brokerage services | Finance |
Massachusetts Institute of Technology
 Massachusetts Institute of Technology Finance/Rental/LeasingFinance Functions as a College/University | Finance |
Addex Therapeutics Ltd.
 Addex Therapeutics Ltd. Pharmaceuticals: MajorHealth Technology Develops and commercializes drugs | Health Technology |
New Leaf Venture Partners LLC
New Leaf Venture Partners LLC Investment ManagersFinance New Leaf Ventures invests in public and private healthcare technology companies located in the US. The firm participates in early and later-stage capital requirements. | Finance |
Health Advances LLC
Health Advances LLC Pharmaceuticals: MajorHealth Technology Provides sciences strategy consulting services to life sciences companies and investors | Health Technology |
Minnesota State University Moorhead
 Minnesota State University Moorhead Other Consumer ServicesConsumer Services Functions as a College/University | Consumer Services |
Karos Pharmaceuticals, Inc.
 Karos Pharmaceuticals, Inc. Pharmaceuticals: MajorHealth Technology Provides pharmaceutical services | Health Technology |
True North Therapeutics, Inc.
 True North Therapeutics, Inc. BiotechnologyHealth Technology Develops novel therapies that selectively inhibit the complement system to treat rare diseases | Health Technology |
ReViral Ltd.
 ReViral Ltd. BiotechnologyHealth Technology Develops novel antiviral therapeutics | Health Technology |
Renovacor Holdings, Inc.
Renovacor Holdings, Inc. BiotechnologyHealth Technology Develops transformative gene therapy | Health Technology |
Chardan Healthcare Acquisition 2 Corp.
 Chardan Healthcare Acquisition 2 Corp. Financial ConglomeratesFinance Operates as blank check company | Finance |
Acorn Capital Advisors LLC
Acorn Capital Advisors LLC Investment ManagersFinance Acorn Bioventures invests in small-cap public and private companies located in the United States. The firm target companies operating in the fields of health & biotechnology sectors. It provides financing for seed, cross-over financings, IPOs, registered direct offerings and PIPEs transactions. | Finance |
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